Treatment of implant-associated infections with moxifloxacin: an animal study

International Journal of Antimicrobial Agents
Thomas KalteisNorbert Lehn

Abstract

The efficacy of moxifloxacin in the treatment of an implant-associated infection by Staphylococcus aureus was compared with vancomycin in an animal study. The femoral medullary cavity of 36 Wistar rats was contaminated with S. aureus (ATCC 29213) and a metal device was implanted. After treatment for 14 days with moxifloxacin (2 x 10 mg/kg/day) or vancomycin (2 x 15 mg/kg/day), the bacterial counts (colony-forming units) in the periprosthetic bone, the soft tissue and the implant-associated biofilm were measured. Compared with the control group, moxifloxacin achieved a highly significant decrease in the microbial counts in the bone and soft tissue and in the biofilm (P<0.001). Moreover, the efficacy of moxifloxacin was significantly greater than that of vancomycin (P<0.01). Vancomycin did not reduce the microbial count significantly compared with the control group (P>0.05). The results justify further investigations of the treatment of implant-associated infections due to S. aureus with moxifloxacin.

Citations

Sep 22, 2010·Antimicrobial Agents and Chemotherapy·Rafael San JuanJose Maria Aguado
Mar 25, 2008·Therapeutics and Clinical Risk Management·David Rp Guay
Aug 18, 2009·Expert Review of Anti-infective Therapy·Olaf Burkhardt, Tobias Welte
Sep 15, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kutay Engin OzturanMelih Guven
Aug 28, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H GaoJ S Lindholt
Jan 12, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H GaoJ S Lindholt

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