Abstract
Rimantadine hydrochloride was administered for 4 days in a small-particle (95% < 6.5 mum) aerosol (8.8 mg/kg per day) or intraperitoneally (40 mg/kg per day) to mice previously infected with influenza A/Aichi/2/68 (H(3)N(2)), mouse adapted. Mean time to death and incidence of survival were significantly increased in all treated groups of mice. The rate of eventual disappearance of virus from lung tissue was also accelerated by therapy. However, maximal mean virus titer per lung, and lung histopathology, did not reveal any difference between control and either group of treated mice. Aerosol therapy initiated at 72 h postinfection was as effective as that initiated at 6 h, even though lung virus titers of these mice had already peaked by 72 h. In contrast, intraperitoneal therapy initiated at 72 h was not effective in all studies.
References
Sep 1, 1971·Southern Medical Journal·G A Pankey
Sep 11, 1969·The New England Journal of Medicine·W L WingfieldR R Grunert
Dec 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·J W McGahen, C E Hoffmann
Sep 1, 1966·Bacteriological Reviews·R B Hornick, H T Eigelsbach
Dec 1, 1952·A.M.A. Archives of Internal Medicine·A L BARACHG J BECK
May 15, 1964·Science·W L DAVIESC E HOFFMANN
Jun 1, 1965·Virology·R R GRUNERTW L DAVIES
Jan 1, 1962·The Journal of Infectious Diseases·W G ROESSLER, D A KAUTTER
Feb 1, 1970·Infection and Immunity·V KnightR B Couch
Citations
Aug 2, 2005·Medical Microbiology and Immunology·A SauerbreiP Wutzler
Sep 1, 1981·Antiviral Research·J M QuarlesC B Goswick
Aug 1, 1982·Antiviral Research·F G HaydenY V Padolka
Apr 1, 1989·Antiviral Research·J E HerrmannF A Ennis
Oct 31, 1981·Lancet·V KnightR B Couch
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Terrence M TumpeyChristopher F Basler
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·E L StephenJ S Walker
Oct 1, 1976·Antimicrobial Agents and Chemotherapy·E W LarsonJ S Walker
Jul 1, 1977·Antimicrobial Agents and Chemotherapy·J B ArensmanD E Hilmas
Feb 1, 1978·Antimicrobial Agents and Chemotherapy·G H ScottR F Berendt
Jan 1, 1982·Antimicrobial Agents and Chemotherapy·J F HruskaR G Douglas
Mar 4, 1977·Annals of the New York Academy of Sciences·E L StephenR F Berendt
Jan 1, 2010·Viruses·Nicole M Bouvier, Anice C Lowen
Oct 27, 2018·Expert Opinion on Drug Discovery·Edin J MifsudAeron C Hurt
Mar 4, 1977·Annals of the New York Academy of Sciences·M Tisdale, D J Bauer
Jun 30, 2019·Applied and Environmental Microbiology·Jennifer D BowlingDouglas S Reed
Apr 1, 1981·Clinical Toxicology·P BassetB Gillet
May 1, 1979·British Journal of Clinical Pharmacology·L F Prescott
Jul 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·R I Davidson
Nov 19, 2020·Vaccines·Irina V KiselevaLudmila V Puchkova
Feb 1, 1977·Journal of Clinical Microbiology·H W YoungE W Larson
Jan 1, 1976·Applied and Environmental Microbiology·E W LarsonJ S Walker
Mar 1, 1979·Infection and Immunity·W C KoffV Knight