Treatment of intracardiac thrombi with argatroban

Acute Cardiac Care
Andreas NiedeggenUwe Janssens

Abstract

Intracardiac thrombi are well known complications associated with diverse cardiac diseases and venous thromboembolism. Therapeutic recommendations like thrombolysis, surgical thrombectomy, or treatment with low molecular heparin and intravenous unfractionated heparin based on small numbers of patients or retrospective case series have failed to reach a consensus. We report on the use of argatroban, a new direct thrombin inhibitor in 4 patients with intracardiac thrombi. Therapy was effective in all patients with complete resolution of thrombi. Treatment was complicated by recurrent strokes with complete neurological recovery in one patient. Therapy of intracardiac thrombi by argatroban is safe and effective. The drug requires no dosage adjustments for age, sex, or renal impairment, including in dialysis-dependent patients. Argatroban has been found to increase predictably activated partial thromboplastin time (aPTT) and activated clotting time (ACT) in a dose-dependent manner.

References

Oct 1, 1988·The Annals of Thoracic Surgery·M NiliM J Levy
Nov 1, 1994·Journal of the American College of Cardiology·S C HeikC Chen
Jun 18, 2003·Pathophysiology of Haemostasis and Thrombosis·Jeanine M Walenga
Jun 18, 2003·Pathophysiology of Haemostasis and Thrombosis·Jawed FareedBruce E Lewis
Jan 13, 2005·American Heart Journal·C Michael White
Sep 9, 2005·The New England Journal of Medicine·Marcello Di NisioHarry R Büller
Sep 15, 2005·Heart and Vessels·Ja Hong Kuh, Yeonho Seo
Jun 20, 2006·American Heart Journal·Robert W Yeh, Ik-Kyung Jang

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Citations

Apr 16, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jürgen LeickHelge Möllmann
Sep 3, 2020·Journal of Biomolecular Structure & Dynamics·Zhipeng TangFei Liu
Jun 8, 2018·Journal of Thrombosis and Thrombolysis·Eiman GhaffarpasandGerald Chi

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