PMID: 7538635Mar 1, 1995Paper

Treatment of intracranial nongerminomatous malignant germ cell tumors producing alpha-fetoprotein

Neurosurgery
Y ItoyamaY Ushio

Abstract

We treated 10 patients with intracranial nongerminomatous malignant germ cell tumors producing alpha-fetoprotein between 1969 and 1992. Two patients were treated with radiotherapy (RT) only (RT group), and three were treated with RT and cisplatin plus vinblastine plus bleomycin therapy with or without surgery (cisplatin plus vinblastine plus bleomycin group). The most recently treated five patients received cisplatin plus etoposide (PE) therapy with or without RT and/or surgery (PE group). The level of alpha-fetoprotein in serum was elevated in all 10 patients. In the PE group, PE therapy consisted of cisplatin (20 mg/m2) and etoposide (60 mg/m2) daily for 5 days (one course) given two or three times at 4-week intervals and then once every 4 months; the patients received three to six courses (mean, 4.2 courses). In the RT group (n = 2), one patient died 3 months after diagnosis and the other died at 12 months. In the cisplatin plus vinblastine plus bleomycin group (n = 3), complete remission was obtained in one patient, but the other two patients died 12 and 24 months after diagnosis. In contrast, in the PE group (n = 5), complete remission was obtained in all patients who are all currently alive without recurrence, at 35 to 71...Continue Reading

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Citations

Jun 2, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S V Roopesh KumarSastry V R Kolluri
Oct 1, 1995·Pediatrics·H C Filston
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·S E SchildP J Schomberg
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y SawamuraH Abe
May 24, 2014·Clinical Biochemistry·Mehmet Kantar
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stewart J KellieJonathan L Finlay
Feb 16, 2019·Pediatric Blood & Cancer·Mohammad H Abu ArjaMohamed S AbdelBaki

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