Treatment of invasive bladder cancer: lessons from the past and perspective for the future

Japanese Journal of Clinical Oncology
Taiji TsukamotoNaoya Masumori

Abstract

Radical cystectomy with lymphadenectomy is the gold standard for treatment of invasive bladder cancer. However, the treatment alone does not always provide a satisfactory result for the disease extending outside the bladder. In this review we discuss several clinical issues in the diagnosis and treatment of this invasive disease. Although the quality of diagnostic imaging modalities has improved, they are still not sensitive enough for the staging of the disease, especially for early invasive disease. In addition, lack of serum markers hinders appropriate monitoring of patients with the disease. Regarding the surgical aspect of lymphadenectomy, the area of its dissection, the standard number of nodes retrieved and the method of pathological examination should be established so that the clinical benefits of surgery can be more clearly defined. Neoadjuvant chemotherapy for invasive disease is promising for improvement of survival of patients. A chemotherapy regimen as effective as, but less toxic than, MVAC (methotrexate, vinblastine, doxorubicin and cisplatin) has been reported and several phase III clinical trials have been launched to determine the benefits of adjuvant or neoadjuvant chemotherapy with newly developed agents. H...Continue Reading

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Citations

Apr 29, 2011·International Journal of Clinical Oncology·Hiroshi KitamuraTaiji Tsukamoto
May 25, 2011·International Journal of Clinical Oncology·Hiroshi KitamuraTaiji Tsukamoto
Jun 15, 2013·Current Urology Reports·Mark W BallMohamad E Allaf
Apr 22, 2011·Annals of Surgical Oncology·George ThemelisVasilis Ntziachristos
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Mar 6, 2007·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Sean McLaughlinRaj S Pruthi
Mar 2, 2006·International Journal of Clinical Oncology·Hiroshi Kitamura, Taiji Tsukamoto

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