PMID: 11916762Mar 28, 2002Paper

Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire

The American Journal of Clinical Nutrition
Sonja Y HessR F Hurrell

Abstract

In many developing countries, children are at high risk of both goiter and iron deficiency anemia. Iron deficiency adversely affects thyroid metabolism and may reduce the efficacy of iodine prophylaxis in areas of endemic goiter. The aim of this study was to determine whether iron supplementation in goitrous, iron-deficient children would improve their response to iodized salt. We conducted a randomized, double-blind, placebo-controlled trial in 5-14-y-old children in Côte d'Ivoire. Goitrous, iron-deficient children (n = 166) consuming iodized salt (10-30 mg I/kg salt at the household level) were supplemented with either iron (60 mg Fe/d, 4 d/wk for 16 wk) or placebo. At 0, 1, 6, 12, and 20 wk, we measured hemoglobin, serum ferritin, serum transferrin receptor, whole-blood zinc protoporphyrin, thyrotropin, thyroxine, urinary iodine, and thyroid gland volume (by ultrasonography). Hemoglobin and iron status at 20 wk were significantly better after iron treatment than after placebo (P < 0.05). At 20 wk, the mean reduction in thyroid size in the iron-treated group was nearly twice that in the placebo group (x +/- SD percentage change in thyroid volume from baseline: -22.8 +/- 10.7% compared with -12.7 +/- 10.1%; P < 0.01). At 20 wk...Continue Reading

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Citations

Jul 26, 2002·The Cochrane Database of Systematic Reviews·T WuC Clar
Jan 24, 2003·The American Journal of Clinical Nutrition·Michael B ZimmermannRichard F Hurrell
Dec 19, 2002·Thyroid : Official Journal of the American Thyroid Association·Michael B Zimmermann, Josef Köhrle
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