PMID: 9179075Jun 1, 1997Paper

Treatment of isolated testicular recurrence of acute lymphoblastic leukemia without radiotherapy. Report from the Dutch Late Effects Study Group

Cancer
H van den BergH Behrendt

Abstract

The isolated recurrence of testicular leukemia in boys with acute lymphoblastic leukemia (ALL) is considered to be an ominous sign, heralding generalized recurrence. In general, treatment is comprised of systemic retreatment and local radiotherapy to one or both affected tests. In this study, the authors report five boys with a late isolated testicular recurrence of ALL during sustained bone marrow remission, in whom radiotherapy had been omitted. High dose methotrexate was included in the treatment regimen. No further recurrences occurred after cessation of therapy. The follow-up period ranged from 1-15 years (median, 8 years). These cases show that there is a subpopulation of boys with recurrence of testicular leukemia who can be treated without radiotherapy. Therefore, the authors propose a treatment regimen for boys with late isolated recurrence of testicular leukemia in which conventional reinduction maintenance treatment is given in combination with high dose methotrexate. Radiotherapy should be withheld until subsequent testicular recurrence occurs.

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Citations

May 4, 2013·The Lancet Oncology·Deepa Bhojwani, Ching-Hon Pui
Oct 13, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroaki Goto
Sep 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Carine DomenechYves Bertrand
Aug 8, 1998·British Journal of Haematology·J M Chessells
Aug 19, 2010·Current Hematologic Malignancy Reports·James E Jacobs, Caroline Hastings
Aug 17, 2012·Blood·Franco LocatelliSergio Rutella
Aug 17, 2020·Practical Radiation Oncology·Erik S BlomainSusan M Hiniker

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