PMID: 1810980Dec 1, 1991

Treatment of keratoacanthomas with intralesional methotrexate

Journal of the American Academy of Dermatology
J L MeltonT M Johnson

Abstract

Multiple modalities exist for the treatment of keratoacanthoma. Excisional surgery is currently the treatment of choice for the majority of keratoacanthomas. This can result in functional and cosmetic defects when large or strategically located lesions are treated. An effective nonsurgical treatment would be desirable in such cases. Intralesional therapy, particularly with 5-fluorouracil, has been shown to be effective in the treatment of keratoacanthomas. Systemic methotrexate has been tried, with variable success. We report an open, noncontrolled study of nine consecutive patients with unusually large or strategically located solitary keratoacanthomas treated successfully with intralesional methotrexate. All lesions responded promptly, with complete resolution after a mean of 3.0 weeks and a mean of 1.7 injections. No side effects occurred, and scarring was minimal. We concluded that intralesional methotrexate is a simple and effective modality for the treatment of select keratoacanthomas and may offer greater efficacy, a more rapid response, decreased pain, and lower cost compared with intralesional 5-fluorouracil.

References

Dec 1, 1979·Journal of Surgical Oncology·R A Schwartz
Jun 1, 1979·Annals of Plastic Surgery·M F Stranc, G A Robertson
Jun 1, 1975·The Journal of Dermatologic Surgery·R S BartS L Gumport
Nov 1, 1989·Archives of Dermatology·K L MageeK Adler-Storthz
Oct 1, 1989·Journal of the American Academy of Dermatology·P A FantiU Bonelli
Jan 1, 1970·Cancer·H MartinR H Spiro
Sep 1, 1969·Archives of Dermatology·K M Burge, R K Winkelmann
Nov 1, 1983·Head & Neck Surgery·N A SwansonS R Baker
Feb 1, 1980·The Journal of Dermatologic Surgery and Oncology·B Kurtis, T Rosen
Mar 1, 1980·Journal of the American Academy of Dermatology·D K Goette, R B Odom
Sep 1, 1965·Archives of Dermatology·J C BELISARIO

Citations

Jun 1, 1995·British Journal of Plastic Surgery·L N Hurst, B S Gan
May 1, 1997·Obstetrics and Gynecology·S GilbeyG P Sutton
Jul 18, 2003·Ophthalmology·Mark J DonaldsonRichard M Williamson
Nov 2, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Scott SandersKishwer S Nehal
Aug 13, 1998·The American Journal of Dermatopathology·J Guitart, K Gordon
Aug 7, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Katelyn ChitwoodGeorge Cohen
Aug 1, 1994·International Journal of Dermatology·W Y WongA Guana
Sep 1, 1996·International Journal of Dermatology·T L FrankS S Greenbaum
Jul 8, 2010·Journal of the American Academy of Dermatology·Joslyn S Kirby, Christopher J Miller
May 17, 2007·Journal of the American Academy of Dermatology·Nicole M AnnestDuane C Whitaker
Apr 21, 2004·Journal of the American Academy of Dermatology·Leonard H GoldbergMurad Alam
Apr 25, 2006·Journal of the American Academy of Dermatology·Sayuri YugeCleverson Teixeira Soares
Apr 25, 2006·Journal of the American Academy of Dermatology·Jonathan E BlumeRichard T Cheney
Aug 4, 2016·JAAD Case Reports·Amy Kalowitz BieberJennifer A Stein
Dec 29, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·G C CanasC J Arpey
Nov 9, 2005·Skinmed·Philip R CohenBruce R Nelson
Mar 24, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kimberly N FlynnDouglas L Smith
Mar 14, 2019·Dermatologic Therapy·Norbert KissNorbert Wikonkál
Oct 9, 2019·Journal of Cutaneous Medicine and Surgery·Edward W SegerTing Wang
Mar 4, 2020·Dermatologic Therapy·Haruki MizutaNaoya Yamazaki
Jan 5, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Max MossAndrew D Montemarano
Jun 21, 2012·Journal of Cutaneous Medicine and Surgery·Nicolas AubutJoël Claveau
Jan 16, 2004·Skinmed·Désirée Ratner
Aug 1, 1997·The Journal of Dermatology·A SingalN Singh
Oct 13, 2020·Dermatologic Therapy·Tamara SearleFiras Al-Niaimi

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