PMID: 8588275Nov 11, 1995Paper

Treatment of keratoconjunctivitis sicca in dogs with cyclosporine ophthalmic ointment: a European clinical field trial

The Veterinary Record
Jane SansomA Weingarten

Abstract

The results are reported of a six-week clinical trial of the efficacy of 0.2 per cent cyclosporine ophthalmic ointment for the treatment of chronic idiopathic keratoconjunctivitis sicca in dogs in the United Kingdom, Germany and France. The 87 dogs were referral cases with a history of chronic unresponsive keratoconjunctivitis sicca of which the aetiology was unknown, and they had to meet stringent criteria before being included in the trial. The clinical response to the therapy was monitored after seven, 21 and 42 days and the results for the right and left eyes were analysed separately. There was a statistically significant increase in lacrimal secretion throughout the study, with most of the increase occurring during the first week of treatment. The percentage of eyes with improved lacrimal secretion was higher in the dogs with initial Schirmer tear test values > or = 2 mm/min than in those with initial values of 0 or 1 mm/min. The observed steady improvement in conjunctival health was not always correlated with an improvement in lacrimal secretion. The incidence of blepharospasm, other signs of discomfort and corneal oedema decreased significantly during the study. No improvement in corneal vascularisation or pigmentation w...Continue Reading

Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·R GurnyV Baeyens
Nov 7, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F LallemandR Gurny
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B C GilgerT Miller
May 24, 2012·TheScientificWorldJournal·Burçin YavuzNurşen Unlü
Dec 5, 2002·The Journal of Small Animal Practice·D L Williams
Jun 9, 2001·Veterinary Ophthalmology·B.C. Gilger, J.B. Allen
Aug 9, 2007·Expert Opinion on Drug Delivery·Hongzhuo LiuSanming Li
Feb 27, 2008·The Veterinary Clinics of North America. Small Animal Practice·David L Williams
Mar 27, 2007·The Journal of Small Animal Practice·R F SanchezF M Billson
Nov 29, 2011·Veterinary Ophthalmology·Mike RhodesPeter Renwick
Apr 28, 2004·The Veterinary Clinics of North America. Small Animal Practice·Cecil P Moore
Apr 16, 2016·Drug Discovery Today·Priyanka Agarwal, Ilva D Rupenthal
Apr 28, 2004·The Veterinary Clinics of North America. Small Animal Practice·Bruce H Grahn, Eric S Storey
Feb 25, 2003·Journal of Cellular Physiology·Salvatore FlorioFerdinando Russo
Feb 7, 2019·Veterinary Ophthalmology·Juliana Kravetz de OliveiraFabiano Montiani-Ferreira
May 10, 2020·Veterinary Ophthalmology·Sara M SmithGustavo D Aguirre
Jul 27, 1999·The Veterinary Record·E M Gonzalez Alonso-AlegreE Rollan Landeras

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