Treatment of large bone defects with a novel biological transport disc in non-vascular transport distraction osteogenesis

International Journal of Oral and Maxillofacial Surgery
J J ZengF C Liao

Abstract

The aim of this study was to investigate a potential novel biological transport disc that avoids secondary injury to the body and facilitates bone healing. Twenty-seven dogs were divided randomly into three groups: group A were treated with human bone morphogenetic protein 2 (BMP-2) modified bone mesenchymal stem cell (BMSC) sheets combined with freeze-dried bone allograft as biological transport disc; group B were treated with BMSC sheets combined with freeze-dried bone allograft as transport disc (control); and group C were treated with direct extension only (blank). There were nine dogs in each group. Non-vascular transport distraction osteogenesis was performed in groups A and B to repair the mandibular bone defects, and in group C only mandibular truncation surgery was performed. The regeneration of bone was evaluated through X-ray, haematoxylin and eosin assay, and immunohistochemistry. After 2, 4, and 8 weeks of distraction, new bone density values in group A were 49.00±1.16, 66.63±2.62, and 72.78±2.67, respectively, and these were significantly different to values in groups B (P=0.0005, P=0.0004, P=0.0012) and C (P<0.0005, P=0.0001, P=0.0003). The average grey value for BMP-2 expression in group A after 4 weeks of distr...Continue Reading

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Citations

Nov 22, 2018·Brazilian Oral Research·Carlos Manuel Rubio MorilloCristina Cunha Villar
Dec 29, 2020·Plastic and Reconstructive Surgery·Harsh N ShahMichael T Longaker
Apr 23, 2021·Tissue Engineering. Part B, Reviews·Francesca MangioneSibylle Vital

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