Abstract
The aim of this study was to investigate a potential novel biological transport disc that avoids secondary injury to the body and facilitates bone healing. Twenty-seven dogs were divided randomly into three groups: group A were treated with human bone morphogenetic protein 2 (BMP-2) modified bone mesenchymal stem cell (BMSC) sheets combined with freeze-dried bone allograft as biological transport disc; group B were treated with BMSC sheets combined with freeze-dried bone allograft as transport disc (control); and group C were treated with direct extension only (blank). There were nine dogs in each group. Non-vascular transport distraction osteogenesis was performed in groups A and B to repair the mandibular bone defects, and in group C only mandibular truncation surgery was performed. The regeneration of bone was evaluated through X-ray, haematoxylin and eosin assay, and immunohistochemistry. After 2, 4, and 8 weeks of distraction, new bone density values in group A were 49.00±1.16, 66.63±2.62, and 72.78±2.67, respectively, and these were significantly different to values in groups B (P=0.0005, P=0.0004, P=0.0012) and C (P<0.0005, P=0.0001, P=0.0003). The average grey value for BMP-2 expression in group A after 4 weeks of distr...Continue Reading
References
Sep 1, 1990·Baillière's Clinical Endocrinology and Metabolism·O Hudlicka
Jan 1, 1987·Microvascular Research·J AndoA Kamiya
May 1, 1980·Clinical Orthopaedics and Related Research·H HanamuraM R Urist
Jul 1, 1982·Annals of Surgery·K Takagi, M R Urist
May 1, 1997·The Journal of Craniofacial Surgery·J W Polley, A A Figueroa
May 20, 1998·The Journal of Craniofacial Surgery·B A TothM Cedars
Aug 27, 1998·Hypertension·S Lehoux, A Tedgui
Oct 18, 2001·Plastic and Reconstructive Surgery·M M MofidC A Vander Kolk
Jun 27, 2002·Transplantation·Roxane PouliotLucie Germain
Dec 5, 2002·The British Journal of Oral & Maxillofacial Surgery·J WiltfangP Kessler
May 4, 2004·Bone·R S CarvalhoL C Gerstenfeld
Aug 16, 2006·Clinical Oral Implants Research·Lisa R AmirAntonius L J J Bronckers
Aug 16, 2006·Clinical Oral Implants Research·Lisa R AmirAntonius L J J Bronckers
Oct 19, 2006·Biomaterials·Yefang ZhouDietmar W Hutmacher
Aug 3, 2007·Development·Arhat AbzhanovClifford J Tabin
Feb 24, 2010·Connective Tissue Research·Dong HanXiaoyi Guan
Dec 3, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Peng GuoNuo Zhou
Citations
Nov 22, 2018·Brazilian Oral Research·Carlos Manuel Rubio MorilloCristina Cunha Villar
Jun 22, 2017·Bone & Joint Research·Y YangG Li
Dec 29, 2020·Plastic and Reconstructive Surgery·Harsh N ShahMichael T Longaker
Apr 23, 2021·Tissue Engineering. Part B, Reviews·Francesca MangioneSibylle Vital