Treatment of Latent Autoimmune Diabetes in Adults: What is Best?

Current Diabetes Reviews
Ingrid K Hals

Abstract

Latent Autoimmune Diabetes in Adults (LADA), although formally classified as Type 1 Diabetes (T1D), very often (at least in Western countries) appear clinically with Type 2 Diabetes (T2D)-like features as overweight and insulin resistance. LADA patients do not need exogenous insulin at the time they are diagnosed with diabetes, but a large percentage will within a few years develop need for such treatment. The decline in beta cell function progresses much faster in LADA than in T2D, presumably because of the ongoing autoimmune assault in LADA, and therefore necessitates insulin therapy much earlier in LADA than in T2D. Despite high prevalence of LADA (about 10% of the total diabetic population in many countries), the treatment of LADA patients is far less elucidated than is the case for T1D and T2D. Finding a treatment strategy for LADA from the time of diagnosis, that can reduce the decline of beta cell function, ensure adequate metabolic control and thereby reduce the risk of diabetic complications is thus an important clinical challenge. Conclusions from the randomized treatment studies so far do not indicate an optimal treatment strategy in LADA. This review aims to give an overview of current practices for the medical trea...Continue Reading

References

Sep 30, 2005·Diabetologia·S FourlanosL C Harrison
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Taro MaruyamaTetsuro Kobayashi
Nov 10, 2011·Diabetes/metabolism Research and Reviews·Akira ShimadaYoichi Oikawa
Jun 16, 2012·Indian Journal of Endocrinology and Metabolism·Resham R Poudel
Jan 25, 2014·Gerontology·Bianca K Itariu, Thomas M Stulnig
Jan 21, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·E LaugesenUNKNOWN Danish Diabetes Academy Workshop and Workshop Speakers
Sep 20, 2015·Diabetes/metabolism Research and Reviews·R BuzzettiB Hirshberg
Jul 9, 2016·Expert Review of Molecular Diagnostics·Johnny Ludvigsson
Jul 28, 2016·Current Diabetes Reports·Jakob Appel ØstergaardR David Leslie
Feb 16, 2017·Diabetes/metabolism Research and Reviews·Alok Kumar, Alberto de Leiva
Jun 14, 2017·The American Journal of Cardiology·James Thrasher

❮ Previous
Next ❯

Citations

Jul 19, 2019·Diabetes/metabolism Research and Reviews·Bingwen LiuZhiguang Zhou
Jan 5, 2021·Chinese Medical Journal·Shuo-Ming LuoZhi-Guang Zhou
Jun 15, 2021·International Immunopharmacology·Shabnam RadbakhshAmirhossein Sahebkar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.