Treatment of left anterior descending coronary artery disease with sirolimus-eluting stents

Circulation
Neil SawhneyPaul S Teirstein

Abstract

Revascularization strategies often hinge on the presence and degree of left anterior descending coronary artery (LAD) stenosis. A decision for bypass surgery is often based on the durability of surgical LAD revascularization compared with percutaneous approaches. By decreasing restenosis, drug-eluting stents may have reduced the "reintervention gap" between surgery and percutaneous intervention, making the percutaneous route preferable. Of the 1101 patients in the SIRIUS trial, 459 with an LAD stenosis were randomized to percutaneous intervention with either sirolimus-eluting or bare-metal stents. Baseline demographic, clinical, and angiographic data were obtained. Patients had 1-year clinical and 8-month angiographic follow-up. Baseline characteristics were similar in both groups. The majority of lesions were tubular type B lesions (69.7%) with a mean diameter of 2.73 mm and a mean length of 14.0 mm. The binary in-stent restenosis rate was 2% for the sirolimus stent group and 41.6% for the bare-metal arm (relative risk, 0.05; 95% CI, 0.02 to 0.1; P<0.001). One-year major adverse events (defined as cardiac death, Q-wave and non-Q-wave myocardial infarction, or target vessel revascularization) was decreased 59% in the sirolimus-...Continue Reading

References

Jan 2, 1986·The New England Journal of Medicine·F D LoopW C Sheldon
Nov 15, 1997·Journal of the American College of Cardiology·A KastratiF J Neumann
Nov 3, 1998·Lancet·K BjøroE Schrumpf
Apr 12, 2001·The New England Journal of Medicine·P W SerruysUNKNOWN Arterial Revascularization Therapies Study Group
Feb 19, 2002·Journal of the American College of Cardiology·Thomas J Vander SalmKatherine M Detre
Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators

❮ Previous
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Citations

Nov 26, 2009·Current Treatment Options in Cardiovascular Medicine·Ramanan UmakanthanJohn G Byrne
Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Holger Thiele, Volkmar Falk
Apr 5, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nikolaos BonarosJohannes Bonatti
Oct 11, 2014·Current Atherosclerosis Reports·Mark Shipeng YuChristopher J Cooper
Nov 12, 2013·International Journal of Cardiology·Fredrik CalaisOle Fröbert
Oct 27, 2012·The Annals of Thoracic Surgery·Victor A FerrarisUNKNOWN Society of Thoracic Surgeons
Oct 22, 2010·Journal of Vascular and Interventional Radiology : JVIR·William D McMillanScott R Schultz
Feb 1, 2008·International Journal of Cardiology·Alberto BerenguerTeresa Lozano
Nov 5, 2004·The Journal of Pharmacy and Pharmacology·Peter BirkenhauerBruno Gander
Nov 21, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Seung-Jung Park
Nov 21, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Konstantinos ToutouzasChristodoulos Stefanadis
Aug 28, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Cheol Whan LeeSeung-Jung Park
Jun 19, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Daniel A JonesAndrew Wragg
Mar 18, 2005·International Journal of Cardiology·Jin Won KimYoung Moo Rho
Nov 25, 2005·The Annals of Thoracic Surgery·Itzhak HerzRephael Mohr
Nov 9, 2005·Cardiovascular Revascularization Medicine : Including Molecular Interventions·José R López-MínguezAntonio Merchán
Apr 24, 2014·The Journal of Thoracic and Cardiovascular Surgery·Ralf E HarskampRobbert J de Winter
Jan 25, 2011·The Annals of Thoracic Surgery·Toshihiro FukuiShuichiro Takanashi
Jan 31, 2006·The American Journal of Cardiology·Eleftheria TsagalouAntonio Colombo
Apr 20, 2005·Journal of the American College of Cardiology·Dean J KereiakesMitchell W Krucoff
Apr 6, 2005·Journal of the American College of Cardiology·William W O'NeillCindy L Grines
May 17, 2005·Journal of the American College of Cardiology·Eleftheria TsagalouAntonio Colombo
May 26, 2009·JACC. Cardiovascular Interventions·John G ByrneDavid X Zhao
Mar 31, 2015·Seminars in Vascular Surgery·Zhen S Huang, Darren B Schneider
Feb 27, 2014·Asian Cardiovascular & Thoracic Annals·Mesut SismanogluKaan Kirali
Oct 26, 2005·Circulation·John S DouglasUNKNOWN Cilostazol for Restenosis Trial (CREST) Investigators
Mar 17, 2005·European Heart Journal·Sigmund SilberUNKNOWN Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology
Oct 4, 2006·The Medical Journal of Australia·Bryan P YanDavid J Clark

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