Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles

Nano Letters
Timothy E MoreyDonn M Dennis

Abstract

Because of its ability to create structures of nanoscale dimension with large aggregate particle surface area-to-volume ratios, nanotechnology offers new opportunities to treat drug poisonings. Emulsion-based nanoparticles (diameter: 118.4 nm) extracted bupivacaine from the aqueous phase in a physiological salt solution and attenuated the drug's cardiotoxicity in guinea pig heart to a greater extent than did a macroemulsion (432.0 nm). Additionally, nanoparticles sequestered bupivacaine from the aqueous phase of human blood and merit further investigation in animal models of intoxication.

References

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Citations

Sep 27, 2006·Anesthesia and Analgesia·Timothy E MoreyDonn M Dennis
May 30, 2006·Anesthesiology·Timothy E MoreyDonn M Dennis
Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Danielle E Turner-Lawrence, William Kerns Ii
Jul 26, 2008·Nature Nanotechnology·Jean-Christophe Leroux
Nov 12, 2010·ACS Nano·Nicolas BertrandJean-Christophe Leroux
Dec 14, 2007·Journal of Colloid and Interface Science·Brett Howell, Anuj Chauhan

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