PMID: 12780444Jun 5, 2003Paper

Treatment of localized prostate cancer using a combination of high dose rate Iridium-192 brachytherapy and external beam irradiation: initial Australian experience

Australasian Radiology
M J StevensJ Martland

Abstract

Combination high dose rate brachytherapy (HDRB) and external beam radiation therapy is technically and clinically feasible as definitive treatment for localized prostate cancer. We report the first large Australian experience using this technique of radiation dose escalation in 82 patients with intermediate- and high-risk disease. With a median follow up of 3 years (156 weeks), complications were low and overall prostate-specific antigen progression-free survival was 91% using the American Society for Therapeutic Radiology and Oncology consensus definition. The delivery of hypofractionated radiation through the HDRB component shortens overall treatment time and is both biologically and logistically advantageous. As a radiation boost strategy, HDRB is easy to learn and could be introduced into most facilities with brachytherapy capability.

References

Dec 1, 1988·The American Journal of Surgical Pathology·J E McNealT A Stamey
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Oct 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J M CrookB Esche
Aug 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F J FowlerL Bin
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J BeardJ A Talcott
Apr 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A L HanlonG E Hanks
Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G BorghedeC Mercke
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·T P MateL Van Hollebeke
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·W S BiceJ C Blasko
Oct 23, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DingesV Budach
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
May 11, 1999·JAMA : the Journal of the American Medical Association·W U ShipleyC D Smith
Jul 8, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G KovácsB Kimming
Aug 5, 1999·Hematology/oncology Clinics of North America·R R RodriguezG A Altieri
Feb 3, 2000·International Journal of Radiation Oncology, Biology, Physics·S NagY Yu
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L L KestinF A Vicini
Sep 7, 2000·International Journal of Radiation Oncology, Biology, Physics·L A DawsonJ M Balter
Jan 25, 2002·Cancer Control : Journal of the Moffitt Cancer Center·A M SyedS J Ko

❮ Previous
Next ❯

Citations

Apr 5, 2013·BJU International·James L SymonsPhillip D Stricker
Aug 15, 2006·International Journal of Radiation Oncology, Biology, Physics·Michael A IzardPhilip Katelaris
Feb 23, 2021·Brachytherapy·Kevin Martell, Marisa A Kollmeier
Apr 29, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Keiichiro MoriShin Egawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved