Treatment of lymphatic malformations of head and neck with OK-432 sclerotherapy induce systemic inflammatory response.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Mervi Närkiö-MäkeläAnne Pitkäranta

Abstract

Systemic immune responses after OK-432 (Picibanil) sclerotherapy in patients with head and neck lymphatic malformations (LM) were examined to achieve a better understanding of the mechanism of OK-432 sclerotherapy and to evaluate the long-term treatment outcome. Serum samples from 17 consecutive patients with head and neck LMs were collected during a total of 26 OK-432 treatment episodes. Serum C-reactive protein (CRP), interleukins (IL) 1β, 6, 8, 10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, RANTES, immune protein (IP)-10 and macrophage chemoattractant protein (MCP)-1 as well as blood leukocyte counts were determined. Clinical outcome of the treatment was evaluated at the last visit and from patient files. Elevated serum levels of IP-10 (means at baseline 702 ng/L, after 1 day 1180 ng/L, after 4 weeks 691 ng/L) were seen on day one after OK-432 sclerotherapy (p < 0.05). C-reactive protein and leukocyte counts 1 day after treatment differed statistically significantly (p < 0.05) from the baseline. No significant differences with other cytokines investigated were observed. Patients with macrocystic LM responded better than patients with microcystic LM (p = 0.01). The elevated levels of IP-10, C-reactive protein and leuk...Continue Reading

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Citations

May 8, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Annamaria Weitz-TuoretmaaJussi Laranne
Jan 3, 2016·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Sophie E R HorbachChantal M A M van der Horst
Mar 23, 2011·International Journal of Pediatric Otorhinolaryngology·Y BajajB E J Hartley
Aug 12, 2016·The Journal of Craniofacial Surgery·Nihal EfeFatih Oner
Jun 28, 2018·Cardiovascular and Interventional Radiology·S E R HorbachJ A Reekers
Oct 26, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Scott C Manning, Jonathan Perkins
Mar 24, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Guy TalmorChristen Caloway

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