Treatment of lymphoblastic lymphoma in adults

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
C N ColemanS A Rosenberg

Abstract

Forty-four adult patients with lymphoblastic lymphoma (LBL) were treated according to one of two protocols. Both included (1) induction with cyclophosphamide, doxorubicin, vincristine, prednisone, and L-asparaginase; (2) CNS prophylaxis; and (3) maintenance therapy with methotrexate (MTX) and 6-mercaptopurine. In the second protocol, CNS prophylaxis began earlier than in the first protocol and included cranial irradiation and intrathecal (IT) MTX rather than simultaneous high-dose systemic and IT MTX. The overall response rate was 100% (95% complete). With a 26-month median follow-up, the 1-and 3-year actuarial freedom from relapse (FFR) for the composite patient group was 70% and 56%, respectively. The incidence of CNS relapse was reduced from 31% in the first protocol to 3% in the second protocol (P = .04, Gehan). Patients can be assigned retrospectively to low (n = 19) and high (n = 25) risk prognostic groups, as indicated by a multivariate analysis of pretreatment prognostic factors. High-risk is defined by Ann Arbor stage IV disease with bone marrow or CNS involvement or initial serum lactate dehydrogenase (LDH) concentration of greater than 300 IU/L (normal, less than 200). FFR of low- and high-risk groups at 5 years are ...Continue Reading

Citations

Jan 1, 1991·Cancer Chemotherapy and Pharmacology·R LiangS L Loke
Oct 1, 1991·Italian Journal of Neurological Sciences·F PisaniG Papa
Jan 1, 1988·European Journal of Haematology. Supplementum·J Ersbøll, H B Schultz
Oct 13, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M Y HamdanR Bick
Nov 29, 2002·Blood·John E LevineUNKNOWN Lymphoma Study Writing Committee, International Bone Marrow Transplant Registry and Autologous Blood and Marrow Transplant R
May 27, 2004·Leukemia & Lymphoma·Perran Fulden YumukOner Dogan
Apr 16, 2008·Transfusion·Elizabeth M Kfoury-BazZiad M Salem
May 7, 2010·Leukemia & Lymphoma·Anne FortuneElisabeth Vandenberghe
Mar 11, 2011·Molecular Biology Reports·Linghao LiChanggeng Ruan
Sep 26, 2012·The Cancer Journal·Craig A Portell, John W Sweetenham
Dec 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristen M O'Dwyer, Anjali S Advani
Apr 14, 2016·British Journal of Haematology·Jessica HochbergOussama Abla
Jan 18, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hye Sun ParkKatherine M Krajewski
Jul 4, 1992·BMJ : British Medical Journal·S E O'Reilly, J M Connors
Oct 1, 1994·Annals of Neurology·D K KaufmanB P O'Neill
Mar 1, 1991·European Journal of Haematology·A K McMillan, A H Goldstone
Jun 1, 1988·Australian and New Zealand Journal of Medicine·K F BradstockM Greenberg
Apr 1, 2005·Leukemia·G W van ImhoffUNKNOWN Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON)
Mar 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yajun GuFang Zheng
Jul 2, 2016·Annals of Hematology·Mona MlikaFaouzi El Mezni
Apr 8, 1993·The New England Journal of Medicine·J O Armitage
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P C BishopP C Elwood
Jan 1, 1996·Acta Oncologica·A Gustafsson
Jun 5, 2004·Blood·Deborah A ThomasHagop Kantarjian
Aug 31, 2006·Yonsei Medical Journal·Wonseok KangWoo Ik Yang
Aug 26, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Il Hwan RyuDong Wook Kang
May 10, 2018·Pediatric Blood & Cancer·Jessica HochbergMitchell S Cairo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.