Sep 1, 1989

Treatment of malignant metastatic midgut carcinoid tumours with recombinant human alpha2b interferon with or without prior hepatic artery embolization

Scandinavian Journal of Gastroenterology
L E HanssenL O Dolva

Abstract

Nineteen patients with histologically verified midgut carcinoid tumours and liver metastases were included in a prospective study with daily recombinant human alpha 2b interferon injections of 5 million IU subcutaneously for 1 year. All had as much as possible of the primary tumour removed at laparotomy. Whenever technically possible (in seven cases), an embolization of the hepatic arteries was performed before interferon start. The response rate of the combined embolization and interferon treatment (n = 7) was 86% after 1 year, as judged from either a 50% reduction in excretion of 5-hydroxy-3-indoleacetic acid in the urine or a 50% reduction in the area of the largest liver metastasis as evaluated by computed tomography. All patients experienced an improvement in diarrhoea and/or flushing. When interferon was given alone (n = 12), 40% responded on the basis of objective criteria (50% after 6 months), whereas an improvement in either diarrhoea or flushing was experienced by 70% (75% after 6 months). In this group one patient had died and one had decided to withdraw after 6 months, at which time both were responders. We conclude that interferon seems to be an effective treatment of malignant metastatic midgut carcinoid tumours a...Continue Reading

  • References21
  • Citations14

Citations

Mentioned in this Paper

Carcinoid Tumor
Carcinoid, Goblet Cell
Tumor Lysis Syndrome
Interferons
Combined Modality Therapy
Deal Barratt Dillon Syndrome
Neoplasm Metastasis
Hepatic Artery
Embolization, Therapeutic
Malignant Neoplasm of Liver

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