PMID: 8952557Dec 15, 1996Paper

Treatment of malignant pleural effusions with a combination of bleomycin and tetracycline. A comparison of bleomycin or tetracycline alone versus a combination of bleomycin and tetracycline

Cancer
A Emad, G R Rezaian

Abstract

Treatment of patients with malignant pleural effusions is mostly palliative. Tetracycline and bleomycin are the two most commonly used agents for the treatment of pleurodesis. In this study, the authors used a combination of the two drugs for this particular purpose. Sixty patients with massive malignant pleural effusions were divided in 3 equal groups in a simple randomized manner. Tetracycline (20 mg/kg [maximum of 2 g] in 50 mL of normal saline) was administered through a chest tube in Group 1. Group 2 received bleomycin (1 U/kg [maximum of 60 U] in 50 mL of normal saline). Group 3 received the above 2 preparations (tetracycline, 20 mg/kg [maximum of 2 g] in 40 mL of normal saline and bleomycin, 1 U/kg [maximum of 60 U] in 30 mL of normal saline) instilled one after the other, while the chest tube was clamped for 5 minutes in the interim. Follow-up examinations were performed at 7 days, 30 days, 60 days, 90 days, and 6 months. There was no significant difference in the complete response rate of the 3 groups during the first 4 months. At the end of the study, Group 3 had a significantly higher complete response rate (70%) compared with Groups 1 and 2 (35% and 25%, respectively) (P = 0.02). The response to use of a combination...Continue Reading

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Citations

Oct 7, 2011·Indian Journal of Palliative Care·Dk MudulyNk Shukla
Sep 11, 2013·Journal of Pain and Symptom Management·Katrin Ruth SigurdardottirDagny Faksvåg Haugen
Oct 2, 2007·Surgical Oncology·Warren J GasperPierre R Theodore
Jun 15, 2007·Seminars in Oncology·Vadim GushchinJohn M Kane
Apr 19, 2005·The Surgical Clinics of North America·Steven J Mentzer
May 28, 2004·Expert Opinion on Pharmacotherapy·Mark Weatherhead, George Antunes
Mar 9, 2017·Expert Review of Respiratory Medicine·José M PorcelY C Gary Lee
Nov 22, 2013·The Cochrane Database of Systematic Reviews·Paul H S Shaw, Roshan Agarwal
May 9, 2016·The Cochrane Database of Systematic Reviews·Amelia O CliveNick Maskell
Oct 28, 2009·American Journal of Clinical Oncology·Giuseppe LombardiDavide Pastorelli
Apr 22, 2020·The Cochrane Database of Systematic Reviews·Alexandra DipperAmelia O Clive

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