Treatment of melasma in men with low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet laser versus combined laser and glycolic acid peeling

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Vasanop VachiramonPunyaphat Sirithanabadeekul

Abstract

Low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet 1,064-nm laser (LFQS) and glycolic acid (GA) peeling have been reported as a treatment option for melasma. However, there are limited data on their efficacy in men. To compare the efficacy and safety of LFQS monotherapy with combined LFQS and 30% GA peeling in male patients with melasma. Fifteen males with mixed type melasma were randomized to receive 5 weekly sessions of LFQS on one side of the face and LFQS plus 30% GA peeling on the contralateral side and were followed for 12 weeks. Twelve patients completed the protocol. Mean relative lightness index (RL*I) of the combined treatment side was lowered throughout the study period, with the maximal improvement of 52.3% reduction at the fourth week follow-up (p = .023). Patient self-assessment was favorable in the combined treatment. However, the mean RL*I increased at 8 and 12 weeks of follow-up. One subject (8.3%) developed guttate hypopigmentation, which did not resolve by the 12-week follow-up. Low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet 1,064-nm laser combined with GA peeling temporarily reduced melasma in men, but the incidence of side effects does not justify the short-lived benefits of this...Continue Reading

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Citations

Jan 7, 2016·Anais Brasileiros De Dermatologia·Emerson de Andrade Lima
Sep 7, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Scott DunbarDavid J Goldberg
Oct 25, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Olabola AwosikaPearl E Grimes
Dec 22, 2017·Indian Journal of Dermatology·Rashmi SarkarV K Somani
Dec 6, 2017·Indian Dermatology Online Journal·Nilendu SarmaBebisha Joseph
Jun 18, 2019·Journal of Cosmetic Dermatology·Madhuri Agarwal, Sangeeta Velaskar
Mar 8, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Laurel M Morton
Dec 6, 2019·American Journal of Clinical Dermatology·Jacqueline McKeseyAmit G Pandya
Mar 6, 2021·Dermatologic Therapy·Behzad IranmaneshMahin Aflatoonian
Apr 15, 2021·The Journal of Dermatological Treatment·Nicoleta NeaguCaterina Dianzani

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