Treatment of metabolic acidosis in patients with CKD

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Wei Chen, Matthew K Abramowitz

Abstract

Metabolic acidosis is a common complication of chronic kidney disease and is believed to contribute to a number of sequelae, including bone disease, altered protein metabolism, skeletal muscle wasting, and progressive glomerular filtration rate loss. Small trials in animal models and humans suggest a role for alkali therapy to lessen these complications. Recent studies support this notion, although more definitive evidence is needed on the long-term benefits of alkali therapy and the optimal serum bicarbonate level. The role of dietary modification also should be given greater consideration. In addition, potential adverse effects of alkali treatment must be taken into consideration, including sodium retention and the theoretical concern of promoting vascular calcification. This teaching case summarizes the rationale for and benefits and complications of base therapy in patients with chronic kidney disease.

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Citations

Apr 6, 2016·The Korean Journal of Internal Medicine·Kyung Yoon ChangYoung Soo Kim
Nov 28, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wei ChenJoachim H Ix
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Jun 25, 2019·Current Opinion in Nephrology and Hypertension·Wei Chen, Matthew K Abramowitz
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Sep 6, 2019·Nephrology·Kamal Kant SahuHouman Javadi
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Mar 30, 2018·CEN Case Reports·Takahiro KasaiHiroshi Itoh
Nov 16, 2017·Life Sciences·Ishfaq A SheikhMohd A Beg

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