In 1972--1973, 785 symptom-free men, aged 40 to 49 years, without target organ damage, with systolic blood pressures between 150 and 179 mm Hg and diastolic blood pressure below 110 mm Hg, were assigned at random to one of two groups: (406 to a drug treatment group and 379 to a control group) for a five-year controlled drug treatment trial to evaluate the effect of therapy on cardiovascular complications. Drug treatment started with hydrochlorothiazide. If systolic blood pressure remained above 140 mm Hg and/or diastolic blood pressure above 90 mm Hg, alphamethyldopa was added. If there were side effects, methyldopa was replaced with propranolol. The control group was not given a placebo. The mean observation time was 66 months (range 60 to 78 months). A difference in blood pressure between groups of about 17 mm Hg systolic and 10 mm Hg diastolic was maintained throughout the study. The study protocol had a rather low "ethical" blood pressure roof, 180 mm Hg systolic and/or 110 mm Hg diastolic. Seventeen percent of the control group had an increase in blood pressure above this level during the trial, and drug treatment was started. There was no effect on major cardiovascular morbidity comparing groups as established by randomiz...Continue Reading
The efficacy of low dose metoprolol CR/ZOK in mild hypertension and in elderly patients with mild to moderate hypertension
Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data and meta-analyses
Coronary heart disease in treated hypertensive patients and risk-matched normotensive control subjects
Trial of antihypertensive interventions and management. Design, methods, and selected baseline results
Prevention of disease progression, left ventricular hypertrophy and congestive heart failure in hypertension treatment trials
Trials of Hypertension Prevention, phase II. Structure and content of the weight loss and dietary sodium reduction interventions. Trials of Hypertension Prevention (TOHP) Collaborative Research Group
Effects of a cardioselective beta-blocker on postprandial triglyceride-rich lipoproteins, low density lipoprotein particle size and glucose-insulin homeostasis in middle-aged men with modestly increased cardiovascular risk
The effect of captopril and metoprolol as monotherapy or combined with bendroflumethiazide on blood lipids
The role of diabetes mellitus and hypertriglyceridaemia as coronary risk factors in treated hypertension: 15 years of follow-up of antihypertensive treatment in middle-aged men in the Primary Prevention Trial in Göteborg, Sweden
Systolic and diastolic blood pressures as predictors of coronary heart disease mortality in the Whitehall study
The case for low dose diuretics in hypertension: comparison of low and conventional doses of cyclopenthiazide
Control of blood pressure and risk of first acute myocardial infarction: Skaraborg hypertension project
Effects of short term beta adrenoreceptor blockade on serum lipids and lipoproteins in patients with hypertension or coronary artery disease
Coronary heart disease in the Medical Research Council trial of treatment of mild hypertension. Medical Research Council Working Party on Mild Hypertension
Generalizability of guidelines and physicians' adherence. Case study on the Sixth Joint National Commitee's guidelines on hypertension
Methods underpinning national clinical guidelines for hypertension: describing the evidence shortfall
Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-analysis
Quality assurance and monitoring in the Hypertension Prevention Trial. Hypertension Prevention Trial Research Group
Preventing cardiovascular disease among Canadians: what are the potential benefits of treating hypertension or dyslipidemia?
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.
Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.