PMID: 16645428Apr 29, 2006Paper

Treatment of mild to moderate psoriasis with Reliéva, a Mahonia aquifolium extract--a double-blind, placebo-controlled study

American Journal of Therapeutics
Steve BernsteinRobert Norman

Abstract

Psoriasis is usually treated with local and systemic medications that have varying degrees of efficacy and safety profiles. We investigated the efficacy and safety of an alternative treatment from natural sources, Mahonia aquifolium, for the management of mild to moderate psoriasis. Two hundred subjects participated in a randomized, double-blind, placebo-controlled study using either the topical cream Reliéva (a homeopathic product containing a proprietary M. aquifolium extract) or control (placebo) twice a day for 12 weeks. Efficacy and safety were assessed using the Psoriasis Area Severity Index (PASI) and the Quality of Life Index (QLI) questionnaires at different times throughout the 12-week study. The PASI was evaluated by the physician at the beginning (week 0) and end (week 12) of the study. The QLI was assessed by patients at weeks 0, 4, 8, and 12. The results indicate statistically significant (P < 0.05) improvements in PASI and QLI in the Mahonia-treated group, compared with the control group. The side effects reported were infrequent, < 1% and minor; the most frequent side effects were rash, a burning sensation when applying the cream, and clothing stain. These data indicate that Reliéva, a proprietary form of M. aqu...Continue Reading

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Citations

Jan 29, 2013·Archives of Dermatological Research·Shiqiang DengCharlie C L Xue
Sep 25, 2007·American Journal of Therapeutics·Howard Donsky, Don Clarke
Jun 1, 2010·American Journal of Clinical Dermatology·Juliane ReuterChristoph M Schempp
Sep 14, 2012·Pharmaceutical Biology·Arshdeep Kaur, Suresh Kumar
Sep 4, 2017·BMC Complementary and Alternative Medicine·Hui-Man ChengC Chris Huang
Nov 23, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Laurence Le CleachOlivier Chosidow
Aug 17, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Juliane ReuterChristoph Schempp
May 30, 2019·International Journal of Molecular Sciences·Tse-Hung HuangJia-You Fang
Aug 6, 2013·The British Journal of Dermatology·S DengC C L Xue
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Anne R MasonHelen Hancock
Nov 26, 2010·Phytotherapy Research : PTR·K SpelmanE J Williams
Jun 15, 2011·The British Journal of Dermatology·T SimonartV De Maertelaer
Mar 16, 2017·American Journal of Clinical Dermatology·Benjamin FarahnikRaja K Sivamani
Feb 13, 2020·Biomedicines·Julia HoffmannUte Wölfle
Nov 17, 2019·Arthritis Care & Research·Nicolas IragorriUNKNOWN Early Detection to Improve Outcome in People With Undiagnosed Psoriatic Arthritis Study Group
Apr 4, 2021·Biomolecules·Fabian GendrischUte Wölfle
Oct 23, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Željan MalešKristina Žužul

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