PMID: 9187476Jun 1, 1997Paper

Treatment of mitochondrial encephalomyopathy with a combination of cytochrome C and vitamins B1 and B2

Brain & Development
J TanakaS Okada

Abstract

The therapeutic efficacy of a regimen consisting of intravenous injection of Cardiocrome, containing cytochrome c, flavin mononucleotide and thiamine diphosphate for mitochondrial encephalomyopathy (MEM) was examined. This combined therapy was applied to nine patients with MEM, including four with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. For the standard regimen, Cardiocrome was first injected daily, usually for 4 weeks, and later by means of intermittent injections for maintenance treatment. Clinical improvement was obtained in eight of the patients. Improvement was observed in the muscle symptoms of easy fatigability, motor disability and severity of stroke-like episodes, as well as in various other symptoms such as phosphate, tinnitus, headache, corneal edema, chilblains, thalamic pain, respiratory failure, and nystagmus. This clinical improvement was maintained for more than 1 year by additional intermittent injections. In conclusion, this therapy was fairly effective for the management of patients with MEM.

References

Jan 18, 1989·Biochimica Et Biophysica Acta·F U HartlW Neupert
Jul 17, 1989·The Medical Journal of Australia·S S GubbayJ M Fry
Jan 1, 1987·Journal of Inherited Metabolic Disease·H Przyrembel
Jan 1, 1986·Neurology·S OgasaharaS Tarui
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S MatsuuraT Morimoto
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S EleffB Chance
Aug 1, 1981·Developmental Medicine and Child Neurology·M G BaalJ C Kok
Mar 1, 1950·The American Journal of Psychiatry·R W GARNETT, W O KLINGMAN
Nov 1, 1945·The Journal of Clinical Investigation·S ProgerG Schmidt
Oct 25, 1946·Science·S Proger, D Dekaneas
Dec 1, 1946·The Journal of Pediatrics·S PROGER, D DEKANEAS

❮ Previous
Next ❯

Citations

Sep 5, 2002·Annals of Neurology·Christian T ShelineDennis W Choi
Apr 3, 2001·Current Treatment Options in Neurology·Roser Pons, Darryl C. De Vivo
Jan 6, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Wenya Linda BiRobert L Lesser
Sep 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J Finsterer
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ludmila A VolobouevaRona G Giffard
Aug 6, 2009·Progress in Neurobiology·Francesca GallettiPaola Sarchielli
Jun 25, 2015·Rinshō shinkeigaku = Clinical neurology·Yasuko KurohaRyoko Koike
Sep 8, 2004·Brain & Development·Masato MoriMariko Y Momoi
Sep 8, 2004·Brain & Development·Masaya KubotaMariko Momoi-Yoshida
Sep 12, 2006·European Journal of Pharmacology·Caryne M BertolloMárcio M Coelho
Jul 21, 2005·The American Journal of Emergency Medicine·Joseph R Shiber
May 4, 2004·Annals of Neurology·Christian T Sheline, Dennis W Choi
Nov 3, 2006·Muscle & Nerve·M Christine RodriguezMark A Tarnopolsky
Oct 24, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Douglas J MahoneyMark A Tarnopolsky
Feb 15, 2020·Microbial Cell Factories·Shuang LiuTao Chen
Apr 23, 2021·Clinical Drug Investigation·Domenico PlantoneGiuseppe Rinaldi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.