PMID: 9446254Jan 31, 1998Paper

Treatment of multidrug resistance in oncology and hematology

Tumori
M Petrini, S Galimberti

Abstract

Drug resistance, which often occurs also during chemotherapy, is yet a great obstacle to the success of the human malignancies treatments. Among many possible mechanisms of drug resistance (biological, biochemical, kinetic or pharmacological), both typical and atypical multidrug-resistance (MDR) have been extensively studied. Multidrug resistance is the phenomenon whereby the development of resistance to one drug is accompanied by the simultaneous development of resistance to a variety of structurally unrelated drugs. Typical MDR seems to depend on the expression of an 170 KD protein, the P-170 or P-glycoprotein, that acts as an energy-dependent pump removing possible toxic agents, including antiblastic drugs, from the cell. High levels of the mdr1 expression have been found in normal adrenal gland, kidney, colon, jejunum and liver, whereas low levels were detected in skin, muscle, brain, nervous system and bone marrow, where CD34+ stem cells are P-170 positive. Moreover, heat shock proteins or oncogene transfection, cell differentiation or proliferation could modulate the P-glycoprotein expression: low protein levels were described in resting B lymphocytes and monoblast cells, whereas plasma cells and monocytes express higher ...Continue Reading

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.