Treatment of multidrug-resistant pulmonary tuberculosis with interferon-gamma via aerosol

Lancet
R CondosN W Schluger

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is associated with substantial morbidity, despite drug therapy. Interferon-gamma, a cytokine produced mainly by CD4 T lymphocytes, can activate alveolar macrophages, important effector cells in host immunity against Mycobacterium tuberculosis. We investigated safety and tolerability of aerosolised interferon-gamma in patients with MDR-TB, and assessed its efficacy in terms of sputum-smear grades. We did an open-label trial of aerosol interferon-gamma given to five patients with smears and cultures positive for pulmonary MDR-TB, despite documented adherence to therapy. The patients received aerosol interferon-gamma 500 micrograms three times a week for 1 month. Safety and tolerability were assessed, and, as well as routine clinical assessments, sputum samples for smear and culture were collected at entry and weekly. Computed tomography scans of the chest were done at baseline and after therapy ended. Interferon-gamma was well tolerated by all patients. In all five, bodyweight stabilised or increased. Sputum acid-fast-bacillus smears became negative in all patients, and the time to positive culture increased (from 17 to 24 days, not significant), which suggested that the mycobacterial bur...Continue Reading

References

Feb 21, 1991·The New England Journal of Medicine·UNKNOWN International Chronic Granulomatous Disease Cooperative Study Group
Aug 1, 1984·The Journal of Experimental Medicine·C F NathanH W Murray
Jul 1, 1995·The European Respiratory Journal·W W Yew, C H Chau
Aug 1, 1995·Annals of Internal Medicine·J I GallinT B Nutman
Jan 1, 1995·Annual Review of Medicine·R E Huebner, K G Castro
Aug 1, 1994·International Archives of Allergy and Immunology·J Vilcek, I C Oliveira
Feb 25, 1993·The New England Journal of Medicine·M GobleC R Horsburgh
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·M M ParkW N Rom

❮ Previous
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Citations

Aug 9, 2003·Current Allergy and Asthma Reports·John Kelly, Warren J Leonard
Jun 19, 2010·Current HIV/AIDS Reports·Umesh G Lalloo, Anish Ambaram
Mar 16, 2000·Developmental and Comparative Immunology·J W LowenthalA G Bean
Oct 16, 1999·International Journal of Pharmaceutics·E KanaokaK Hirano
Jun 19, 2003·Diagnostic Microbiology and Infectious Disease·Naoko InokuchiShimeru Kamihira
Aug 6, 2002·Trends in Microbiology·Zahra Toossi
Apr 24, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dulce A Mata-EspinosaRogelio Hernández-Pando
Aug 9, 2008·The New England Journal of Medicine·Carole D MitnickMercedes C Becerra
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J J EllnerC C Whalen
Dec 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L V SacksS Hurwitz
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert S Wallis
Sep 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ernest C Borden
May 26, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rajko Reljic
Mar 30, 2012·The Journal of Infectious Diseases·Michael UhlinMarkus Maeurer
Mar 12, 2013·The Journal of Infectious Diseases·Ka-Wing Wong, Williams R Jacobs
Apr 27, 2000·Current Opinion in Pulmonary Medicine·P A Willcox
Apr 4, 2006·Current Opinion in Pulmonary Medicine·Umesh G LallooAnish Ambaram
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wing Wai Yew, Chi Chiu Leung
Feb 3, 2006·International Journal of Clinical Practice·S Alazemi, M A Campos
Dec 7, 2011·Antimicrobial Agents and Chemotherapy·Chad J RoyDeepak Kaushal
Dec 19, 2001·Infection and Immunity·Nicole P JuffermansTom van der Poll
Apr 13, 2005·Respiration; International Review of Thoracic Diseases·Mario CazzolaGabriella Pezzuto
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·R CondosN W Schluger
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·N W Schluger, W N Rom
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·S GiosuéF Ameglio
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·K M Tchou-WongW N Rom
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·P F Barnes, B Wizel
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Henry M BlumbergUNKNOWN American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society
Nov 16, 2002·American Journal of Respiratory and Critical Care Medicine·Paul T KingStephen R Holdsworth
May 13, 2006·American Journal of Respiratory and Critical Care Medicine·Graham S CookeAdrian V S Hill
Jul 10, 2003·American Journal of Respiratory and Critical Care Medicine·Peter F Barnes
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Jessica WalrathRichard F Silver
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Neil W Schluger
Mar 20, 2002·The Journal of Clinical Investigation·Robert M StrieterMichael P Keane
Oct 27, 2004·BMC Infectious Diseases·Roberto Suárez-MéndezPedro A López-Saura
Feb 13, 2008·BMC Infectious Diseases·María T Milanés-VirellesUNKNOWN MACGAM Study Group
Oct 23, 2001·Respiratory Research·J K Kolls, S Nelson

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