Treatment of multifocal atrial tachycardia with metoprolol

Critical Care Medicine
P B Hazard, C R Burnett

Abstract

We used metoprolol orally or iv in 25 patients with multifocal atrial tachycardia that was complicating severe cardiopulmonary illness, and we observed its effect on heart rate and rhythm, BP, and arterial blood gases. All patients showed a dramatic slowing of heart rate, averaging 54.0 +/- 4.0 beat/min (p less than .001), with only small and transient fall in BP. Seventeen (68%) patients experienced conversion to sinus rhythm, 11 immediately, and six more within 3 h. Time to response averaged 5.1 h with the oral form but was less than 10 min when the drug was given iv. The mean oral dose required was 32.5 mg, and the mean iv dose was 6.5 mg. No patient experienced clinically apparent hemodynamic or respiratory deterioration as a result of metoprolol administration. While arterial pH and PaCO2 were unaltered by metoprolol, mean PaO2 increased by 12.2 +/- 5.8 torr (p less than .05), the increase being greatest in patients with more severe gas-exchange derangement. We conclude that metoprolol is effective in the management of multifocal atrial tachycardia.

Citations

Jun 14, 1990·The New England Journal of Medicine·J A Kastor
Jun 20, 1998·Postgraduate Medicine·Y Y Mishriki
Jun 1, 1992·Chest·G A Hill, S D Owens
Feb 1, 1988·Chest·E C Huycke, R J Sung
Nov 20, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Demosthenes G KatritsisJack Rickard
Jan 1, 1991·Scandinavian Journal of Infectious Diseases·J RelloG Prats
Oct 1, 1989·Postgraduate Medicine·S L Lawhorn, W W Emmot

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