Treatment of muscle-invasive bladder cancer: A systematic review

Cancer
Roger ChouJohn L Gore

Abstract

There is uncertainty regarding the use of bladder-sparing alternatives to standard radical cystectomy, optimal lymph node dissection techniques, and optimal chemotherapeutic regimens. This study was conducted to systematically review the benefits and harms of bladder-sparing therapies, lymph node dissection, and systemic chemotherapy for patients with clinically localized muscle-invasive bladder cancer. Systematic literature searches of MEDLINE (from 1990 through October 2014), the Cochrane databases, reference lists, and the ClinicalTrials.gov Web site were performed. A total of 41 articles were selected for review. Bladder-sparing therapies were found to be associated with worse survival compared with radical cystectomy, although the studies had serious methodological shortcomings, findings were inconsistent, and only a few studies evaluated currently recommended techniques. More extensive lymph node dissection might be more effective than less extensive dissection at improving survival and decreasing local disease recurrence, but there were methodological shortcomings and some inconsistency. Six randomized trials found cisplatin-based combination neoadjuvant chemotherapy to be associated with a decreased mortality risk versu...Continue Reading

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Citations

Jun 22, 2016·Investigative and Clinical Urology·Thenappan Chandrasekar, Christopher P Evans
Jun 22, 2017·Oncology Nursing Forum·Kyle MerandyDouglas S Scherr
Apr 4, 2019·Frontiers in Oncology·Larry BodgiWassim Abou-Kheir
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Aug 28, 2021·Advanced Materials Technologies·Nihan Yonet-TanyeriSteven R Little
Oct 13, 2021·Expert Opinion on Therapeutic Targets·Pratishtha GuptaMinal Garg

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