PMID: 3755864Oct 1, 1986Paper

Treatment of myelodysplastic syndrome with 1.25-dihydroxy-vitamin D3

American Journal of Hematology
C RichardA Zubizarreta

Abstract

1.25-dihydroxy-vitamin D3 (1.25 (OH)2D3) was tested in seven patients with myelodysplastic syndrome. The study was undertaken because 1.25 (OH)2D3 promotes differentiating myeloid cells in vitro and because of a prior report of potential benefit in a clinical study. The drug was given orally at a dose of 2.5 micrograms/day for a minimum of 8 weeks (range 8-28). After therapy, there were no significant changes in any of the parameters observed in peripheral blood or bone marrow. We did not observe any feature of granulocytic-monocytic differentiation. Treatment was well tolerated. One patient died because of bone marrow failure. Survivors have persisting myelodysplastic syndrome and continue to be transfusion dependent. 1.25 (OH)2D3 has no beneficial effect in patients with myelodysplastic syndrome with this dose regimen.

References

Sep 29, 1984·Lancet·A B MehtaD M McCarthy
Dec 29, 1983·The New England Journal of Medicine·J S WischD W Kufe

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Citations

Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I Blazsek, G Mathé
Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L De RosaA De Laurenzi
Aug 1, 1995·Journal of Hematotherapy·A B SchultzC D Hillyer
Oct 25, 2002·Leukemia & Lymphoma·H M Hirri, R J Green
Jun 17, 2008·Molecular Aspects of Medicine·Alex J Brown, Eduardo Slatopolsky
Sep 17, 2005·Leukemia Research·H Phillip KoefflerJames O'Kelly
Sep 30, 1998·British Journal of Haematology·V Santini, P R Ferrini
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·István MolnárGary G Schwartz

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