Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease

Current Treatment Options in Neurology
Panagiotis Zis, Marios Hadjivassiliou

Abstract

The aim of this paper was to overview the current literature in order to establish the available treatment options for the neurological manifestations of gluten-related disorders (serologically confirmed gluten sensitivity and coeliac disease). A range of debilitating neurological manifestations is increasingly being recognized in patients with gluten sensitivity with and without enteropathy even in the absence of gastrointestinal symptoms. Ataxia is the commonest neurological manifestation, followed by peripheral neuropathy. Epilepsy, headache, encephalopathy, various movement disorders, cognitive impairment, and muscle disorders have also been linked to gluten sensitivity and coeliac disease and are discussed in this review. Strict gluten-free diet is an effective first-line treatment of the neurological manifestations of gluten-related disorders. Very few patients will require additional immunosuppressive treatment usually in the form of mycophenolate.

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Citations

Nov 30, 2019·Practical Neurology·Stela LefterMarios Hadjivassiliou
Jun 24, 2020·Journal of Internal Medicine·A RejD S Sanders
Nov 26, 2020·Metallomics : Integrated Biometal Science·Jemmyson Romário de Jesus, Marco Aurélio Zezzi Arruda
Apr 27, 2021·Pharmacology & Therapeutics·Xiao-Yuan MaoWei-Lin Jin
Oct 24, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Shokufeh BagheriAlireza Komaki
Jan 13, 2022·The Cerebellum·Sergio Muñiz-CastrilloJérôme Honnorat

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