PMID: 8609099Jan 1, 1996Paper

Treatment of nocturnal asthma by addition of oral slow-release albuterol to standard treatment in stable asthma patients

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
A R Van KeimpemaP E Postmus

Abstract

Nocturnal and early-morning complaints in asthma patients are sometimes difficult to treat. We investigated the efficacy of an oral osmotically controlled release (OR) formulation of albuterol 8 mg in 35 patients with stable asthma and nocturnal complaints and/or morning dipping of the peak expiratory flow (PEF). The mean age was 45 years (range 22-70), the FEV(1) was 61 +/- 20% of predicted, and inhaled steroids were used by 32 patients. Albuterol OR was added to their usual treatment. The use of theophyllines and oral adrenergics was not allowed. Twice-daily (b.i.d.) dosing was compared to one dose at night and to placebo. The three-period crossover study was double-blind placebo-controlled with treatment periods of 2 weeks. Responses have been analyzed by means of multiple regression analysis at a significance level of 5%. There was no significant difference of the FEV(1) or the weekly means of PEFs between the periods. During the b.i.d. treatment, the daytime and nocturnal symptom scores, used rescue medication, subjective sleep quality, and nocturnal waking tended to be better. Mental fitness was improved, but significantly only in the morning. We concluded that additional treatment with albuterol 8 mg OR once or twice dai...Continue Reading

References

Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W W StormsC W Zwillich
Apr 18, 1992·BMJ : British Medical Journal·J B MacDonald
May 1, 1990·British Journal of Clinical Pharmacology·R MilroyG Boyd
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Citations

Aug 28, 1998·Journal of Psychosomatic Research·J S Carpenter, M A Andrykowski
Aug 27, 2014·Clinics in Chest Medicine·Wajahat H KhanCarolyn M D'Ambrosio
Oct 8, 1999·Chronobiology International·B G Bender, R D Annett
Apr 29, 1998·Clinics in Chest Medicine·C M D'Ambrosio, V Mohsenin

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