Treatment of node-positive endometrial cancer with complete node dissection, chemotherapy and radiation therapy

British Journal of Cancer
T OndaY Taketani

Abstract

We assessed the therapeutic significance of systematic aortic and pelvic lymphadenectomy followed by adjuvant therapy in node-positive endometrial carcinoma. Among 173 stage I-III patients, 30 (17%) had positive nodes: ten in the pelvic region alone (group P) and 20 in the aortic region alone or in both regions (group A). The adjuvant therapy was administered as follows: subjects in group P received 50 Gy pelvic radiation, including three post-surgical T3 (pT3) patients who received either one or three cycles of cisplatin-based chemotherapy before radiation. Subjects in group A were given three cycles of chemotherapy followed by 50 Gy pelvic and 50 Gy extended field periaortic radiation using a four-field or conformational technique. Five-year survival was 95% for 143 patients with negative nodes and 84% for 30 patients with positive nodes (100% for group P and 75% for group A). In group A, 5-year survival was 38% for eight patients with both pT3 and histology other than endometrioid type G1, and 91% for the remaining 12 patients. Either way, both group P and group A patients had a better prognosis than previously reported. In summary, aortic and pelvic lymphadenectomy and subsequent chemotherapy and radiation therapy based on ...Continue Reading

Citations

Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T. KasamatsuT. Shirai
May 25, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Yasuhiko EbinaSeiichiro Fujimoto
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K W K LoT K H Chung
Dec 27, 2005·Expert Review of Anticancer Therapy·Jonathan Carter, Selvan Pather
Jun 24, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciAndrea Riccardo Genazzani
Jun 15, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Eiji RyoTakuya Ayabe
Feb 23, 2012·Journal of Gynecologic Oncology·Lisa N AbaidBram H Goldstein
Dec 18, 2015·Journal of Gynecologic Oncology·Alessandro BudaRodolfo Milani
Apr 18, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Marie SatoTomoyuki Fujii
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K. GersztenQ. Huang
Dec 23, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E RyoY Taketani
Mar 11, 2005·Expert Review of Anticancer Therapy·Margrit M JuretzkaYukio Sonoda
Jan 7, 2009·Current Opinion in Obstetrics & Gynecology·Toshio FujimotoToshinobu Tanaka
Apr 21, 2012·Obstetrics and Gynecology International·Mohamed K Mehasseb, John A Latimer
Oct 13, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hitoshi HareyamaKazuhiko Okuyama
Apr 25, 2014·Journal of Gynecologic Oncology·Maria C DeleonDaniela Matei
Mar 22, 2016·Expert Review of Anticancer Therapy·David G Mutch, Marquerite Palisoul
May 10, 2017·Journal of Surgical Oncology·Glauco BaiocchiAlexandre Andre Balieiro Anastacio da Costa
Jul 22, 2019·International Journal of Environmental Research and Public Health·Yi-Jou TaiWen-Fang Cheng
Feb 22, 2003·Current Treatment Options in Oncology·D Scott McMeekin, Todd Tillmanns
Mar 27, 2001·Acta Obstetricia Et Gynecologica Scandinavica·E RyoY Taketani
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H NomuraS Nozawa
Aug 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Masamichi HiuraJunko Wroblewski
Dec 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marcus E RandallUNKNOWN Gynecologic Oncology Group Study
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R E BristowF J Montz
Nov 27, 2008·Journal of the National Cancer Institute·Pierluigi Benedetti PaniciCostantino Mangioni
Jan 27, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Melissa Rasar YoungShari Damast
Oct 16, 2004·Current Oncology Reports·Gunnar Kristensen, Claes Tropé
Mar 22, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pluvio J CoronadoMiguel A Herraiz
Jun 24, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E Ryo
Jul 11, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiAndrea Mariani
May 1, 2021·Journal of Clinical Medicine·Camille SalléeTristan Gauthier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.