Abstract
Reflux of duodenal juice into the oesophagus has a role in the pathogenesis of both oesophageal and laryngopharyngeal inflammatory and neoplastic lesions. As little is known about effective therapy, we studied the effect of proton pump inhibitor therapy on oesophageal bile reflux in children. Twenty-nine children with moderate to severe erosive oesophagitis and abnormal oesophageal bile reflux were studied before and after treatment with omeprazole 1 mg/kg per day. Outcomes included a clinical symptom score, oesophageal acid and bile reflux (simultaneous 24-hour pH and Bilitec 2000 monitoring), and mucosal healing. After 8 weeks of therapy, 17 (59%) of the patients were symptom-free, and 5 (17%) had minimal symptoms. Mucosal healing or reduction to low-grade oesophagitis was achieved in 25 children (86%; P < 0.0005). Mean percentages of total, upright, and supine time with oesophageal pH less than 4 were reduced from 17.0%, 16.8%, and 19.2% before treatment, to 2.83%, 3.17%, and 2.07%, respectively, after treatment (all P < 0.00001). Similarly, mean percentages of total, upright, and supine time with bile reflux were reduced from 16.96%, 12.67%, and 22.0%, to 2.27%, 1.91%, and 2.23%, respectively (P < 0.000001, P < 0.0001, and ...Continue Reading
References
Jan 1, 1992·Gastroenterology·S J SontagG Ahtaridis
Jan 1, 1995·American Journal of Surgery·W K KauerT R DeMeester
Sep 1, 1994·Gastroenterology·G ChampionR Alexander
Jul 1, 1993·Digestive Diseases and Sciences·P BechiS Boscherini
May 1, 1996·Gastroenterology·U BeuersJ L Boyer
Apr 1, 1996·Digestive Diseases and Sciences·M F VaeziJ E Richter
Apr 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·E Hassall
Oct 1, 1996·Gastroenterology·D I Soybel
Nov 1, 1996·Gastroenterology·M F Vaezi, J E Richter
Feb 19, 1998·The American Journal of Gastroenterology·D L EarnestP A Greski-Rose
Nov 21, 1998·Gut·R E MarshallW J Owen
Dec 8, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·H J SteinJ R Siewert
Jul 14, 1999·Gut·L R LundellL Wallin
Oct 27, 1999·Gastroenterology·A LehmannL Kärrberg
Dec 13, 2000·The Journal of Pediatrics·E HassallP Lundborg
Mar 22, 2001·Digestive Diseases and Sciences·R CuomoJ Tack
Apr 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·D PashankarD M Israel
Jun 7, 2002·Journal of Pediatric Gastroenterology and Nutrition·Tobias G WenzlHeino Skopnik
Aug 13, 2002·Gut·M F DixonA T R Axon
Oct 9, 2002·The Laryngoscope·J GalliG Almadori
Jan 22, 2003·Alimentary Pharmacology & Therapeutics·M F VelaD O Castell
Jan 28, 2003·Journal of Pediatric Gastroenterology and Nutrition·Rok Orel, Sasa Markovic
Feb 28, 2003·Journal of Pediatric Gastroenterology and Nutrition·Vasundhara ToliaRobert Kane
Feb 28, 2003·Journal of Pediatric Gastroenterology and Nutrition·Vasundhara ToliaLinda Book
Feb 28, 2003·Journal of Pediatric Gastroenterology and Nutrition·Thirumazhisai GunasekaranJoseph Fitzgerald
Jun 5, 2003·The Laryngoscope·Myung-Whun SungKwang Hyun Kim
Jun 13, 2003·ANZ Journal of Surgery·Alexandros FountosEvaghelos Xynos
Jul 2, 2003·European Journal of Pediatrics·Dominique HermansJean-Paul Buts
Aug 20, 2003·Digestive Diseases and Sciences·Jean-Pierre RaufmanPiotr Zimniak
Sep 13, 2003·Gut·G H KoekJ Tack
Nov 19, 2003·Scandinavian Journal of Gastroenterology·K SzentpáliM Boros
Dec 6, 2003·Carcinogenesis·G J S JenkinsJ M Parry
Dec 20, 2003·Gut·T J JangW S Ahn
Dec 20, 2003·Journal of Pediatric Gastroenterology and Nutrition·Richard B Colletti, Carlo Di Lorenzo
Jan 16, 2004·Current Treatment Options in Gastroenterology·Joel E. Richter
Feb 28, 2004·Carcinogenesis·Urmi ChatterjiGary L Firestone
Apr 23, 2004·Life Sciences·Atsushi KawabeMasayuki Imamura
May 12, 2004·Archives of Surgery·Abeezar I SarelaGeoffrey W B Clark
Jun 8, 2004·The American Journal of Gastroenterology·J TackJ Janssens
Dec 29, 2004·Annals of Surgery·Jörg TheisenPeter W Laird
Mar 19, 2005·Digestion·Elfriede BollschweilerArnulf H Hölscher
Apr 14, 2005·The Annals of Otology, Rhinology, and Laryngology·Clarence T SasakiRichard N Eisen