Treatment of osteochondral lesions in the knee using a cell-free scaffold

The Bone & Joint Journal
P VerdonkJ Victor

Abstract

The treatment of osteochondral lesions is of great interest to orthopaedic surgeons because most lesions do not heal spontaneously. We present the short-term clinical outcome and MRI findings of a cell-free scaffold used for the treatment of these lesions in the knee. A total of 38 patients were prospectively evaluated clinically for two years following treatment with an osteochondral nanostructured biomimetic scaffold. There were 23 men and 15 women; the mean age of the patients was 30.5 years (15 to 64). Clinical outcome was assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS), the Tegner activity scale and a Visual Analgue scale for pain. MRI data were analysed based on the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring system at three, 12 and 24 months post-operatively. There was a continuous significant clinical improvement after surgery. In two patients, the scaffold treatment failed (5.3%) There was a statistically significant improvement in the MOCART precentage scores. The repair tissue filled most of the defect sufficiently. We found subchondral laminar changes in all patients. Intralesional osteophytes were found in two patients (5.3%). We conclude that this one-step scaf...Continue Reading

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Citations

Apr 20, 2016·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Renato AndradeJoão Espregueira-Mendes
Sep 12, 2016·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Hakan SofuVedat Sahin
Jul 12, 2017·British Journal of Hospital Medicine·Yusuf H Mirza, Sam Oussedik
Sep 16, 2017·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Elizaveta KonMaurilio Marcacci
Sep 8, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Theofylaktos KyriakidisRené Verdonk
Feb 14, 2020·Cartilage·Bjørn Borsøe ChristensenMartin Lind
Jan 6, 2017·The Bone & Joint Journal·F S Haddad
Apr 8, 2017·The Bone & Joint Journal·F S Haddad
Jul 12, 2017·Journal of Tissue Engineering·Altug YucekulMahmut Nedim Doral
Jul 25, 2019·AAPS PharmSciTech·Nermeen A Elkasabgy, Azza A Mahmoud
Dec 4, 2017·Polymers·Daniela Anahí Sánchez-TéllezLuís María Rodríguez-Lorenzo
Jun 5, 2019·Journal of Clinical Medicine·Riccardo D'AmbrosiFederico Giuseppe Usuelli
Sep 29, 2015·Current Reviews in Musculoskeletal Medicine·M Zain MirzaScott A Lynch
Jun 20, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·L ChadliN Pujol
Jun 17, 2021·Revista española de cirugía ortopédica y traumatología·J M BogalloE Guerado

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