PMID: 6989171Jan 1, 1980Paper

Treatment of osteoporosis with 1-alpha-hydroxycholecalciferol and calcium

Acta Medica Scandinavica
V HoikkaV Rehnberg

Abstract

A double-blind comparative study of 1 alpha-OHD3 and placebo was performed on 37 patients with osteoporotic hip fracture without clinical osteomalacia. 1 alpha-OHD3, in a dose of 1 microgram/day together with 2.5 g CaCO3, did not heal osteoporosis as judged from determinations of bone mineral density and histomorphometric analyses during four months of treatment. However, 1 alpha-OHD3 seemed to have an effect on fracture healing as concluded from the posttreatment alkaline phosphatase level. Hypercalcemia was common, occurring in six out of 19 patients treated with 1 alpha-OHD3. It is concluded that treatment of osteoporosis with 1 alpha-OHD3 and calcium is ineffective and potentially dangerous because it frequently causes hypercalcemia.

References

Dec 1, 1977·Clinical Endocrinology·O H SørensenL Mosekilde
Apr 1, 1978·Acta Orthopaedica Scandinavica·B LamkeM Sylvén
Dec 1, 1978·Acta Orthopaedica Scandinavica·T S Lindholm, J A Sevastikoglou
Jun 1, 1976·The Journal of Clinical Endocrinology and Metabolism·B L RiggsC D Arnaud
Oct 24, 1974·The New England Journal of Medicine·P BordierH Rasmussen
Jun 1, 1974·Acta Medica Scandinavica·K BuringP E Wiklund
Apr 1, 1968·The Journal of Pathology and Bacteriology·C G WoodsH H Gossmann

Citations

Sep 1, 1985·Clinical Rheumatology·M CarrozzoV Pipitone
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisD M Zhang
Sep 1, 1988·Journal of the American Geriatrics Society·J E MorleyF E Kaiser
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M Shiraki
Feb 1, 1982·Journal of the American Geriatrics Society·L G Raisz
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A TokitaJ A Eisman
Jun 23, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F Massart
Aug 1, 1981·European Journal of Clinical Investigation·C ChristiansenI Transbøl

Related Concepts

Skeletal Bone
Calcium
Clinical Trials
Double-Blind Method
Trochanteric Fractures
Hydroxycholecalciferols
Minerals
Muscle
Post-Traumatic Osteoporosis
Placebos

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