Abstract
Pachyonychia congenita (PC) is a rare genodermatosis which may be associated with painful, focal hyperkeratosis on the soles. Plantar sweating at high ambient temperatures increases the blistering of the callosities. We report three patients with PC who had great problems in walking, especially during summer time. They were treated with intracutaneous plantar injections of botulinum toxin type A (Dysport, 100 U mL(-1); Ipsen, Slough, U.K.) after prior intravenous regional anaesthesia of the foot with a low tourniquet and 25 mL prilocaine (5 mg mL(-1)). Within a week all three patients experienced dryness and a remarkable relief of pain from plantar pressure sites. The effect duration was 6 weeks to 6 months. Repeated injections over a 2-year period confirmed the good results, with no side-effects or tachyphylaxis noted.
References
Jan 1, 1986·Annual Review of Pharmacology and Toxicology·L L Simpson
Apr 1, 1981·The British Journal of Dermatology·A RehákG Yadav
Feb 15, 2001·The New England Journal of Medicine·M HeckmannUNKNOWN Hyperhidrosis Study Group
May 22, 2001·The British Journal of Dermatology·C S Munro
Sep 15, 2001·BMJ : British Medical Journal·M Naumann, N J Lowe
Aug 14, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hans-Juergen BlahetaGernot Rassner
Feb 8, 2003·Journal of Neurology·H H KrämerF Birklein
Sep 27, 2003·The British Journal of Dermatology·M J HaytonN J Lowe
Jan 8, 2004·The Journal of Investigative Dermatology·Maurice A M van SteenselFrances J D Smith
Jul 29, 2004·Journal of the American Academy of Dermatology·John HornbergerUNKNOWN Multi-Specialty Working Group on the Recognition, Diagnosis, and Treatment of Primary Focal Hyperhidrosis
Nov 4, 2004·Journal of the American Academy of Dermatology·Carl SwartlingAnders Vahlquist
Citations
Aug 28, 2007·Journal of Dermatological Science·Haihui LiaoFrances J D Smith
Jul 14, 2010·The British Journal of Dermatology·C SwartlingA Vahlquist
Feb 22, 2011·Journal of Cosmetic Dermatology·Amir FeilyHossein Kalantar
Mar 30, 2010·The British Journal of Dermatology·M ZamiriC S Munro
May 8, 2010·Dermatologic Clinics·Anders Vahlquist, Kaisa Tasanen
Mar 28, 2017·The British Journal of Dermatology·L RittiéF J D Smith
Apr 8, 2017·Aesthetic Surgery Journal·Joel SchlessingerJoely Kaufman
Oct 28, 2017·Journal of the American Podiatric Medical Association·Rebecca M PorterFrances J D Smith
Oct 12, 2018·The British Journal of Dermatology·F AbdollahimajdJ Uitto
Jun 22, 2012·Experimental Dermatology·Jean Christopher ChamcheuHasan Mukhtar
Mar 19, 2019·The British Journal of Dermatology·R L WeinbergM J Caterina
Jul 26, 2019·A&A Practice·Jed M PaulXiang Qian
May 18, 2016·A & a Case Reports·Sarah TariqMegha Karkera Kanjia
Jul 12, 2020·American Journal of Clinical Dermatology·Tina S Alster, Iris S Harrison
Dec 27, 2019·The British Journal of Dermatology·B R Thomas, A Sahota
Sep 2, 2014·Dermatologic Therapy·Anna JirákováJana Hercogová
Aug 30, 2018·The British Journal of Dermatology·M A Krupiczojc, E A O'Toole
May 28, 2019·The British Journal of Dermatology·A KorenO Artzi
Oct 8, 2015·Dermatologic Therapy·Jéssica González-RamosPedro Herranz-Pinto
Feb 11, 2021·Toxins·Emanuela MartinaAnnamaria Offidani
Jun 12, 2021·The Journal of Investigative Dermatology·Tiffany T WuJoyce M C Teng