Treatment of pachyonychia congenita with plantar injections of botulinum toxin

The British Journal of Dermatology
C Swartling, A Vahlquist

Abstract

Pachyonychia congenita (PC) is a rare genodermatosis which may be associated with painful, focal hyperkeratosis on the soles. Plantar sweating at high ambient temperatures increases the blistering of the callosities. We report three patients with PC who had great problems in walking, especially during summer time. They were treated with intracutaneous plantar injections of botulinum toxin type A (Dysport, 100 U mL(-1); Ipsen, Slough, U.K.) after prior intravenous regional anaesthesia of the foot with a low tourniquet and 25 mL prilocaine (5 mg mL(-1)). Within a week all three patients experienced dryness and a remarkable relief of pain from plantar pressure sites. The effect duration was 6 weeks to 6 months. Repeated injections over a 2-year period confirmed the good results, with no side-effects or tachyphylaxis noted.

References

Jan 1, 1986·Annual Review of Pharmacology and Toxicology·L L Simpson
Apr 1, 1981·The British Journal of Dermatology·A RehákG Yadav
Feb 15, 2001·The New England Journal of Medicine·M HeckmannUNKNOWN Hyperhidrosis Study Group
May 22, 2001·The British Journal of Dermatology·C S Munro
Aug 14, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hans-Juergen BlahetaGernot Rassner
Sep 27, 2003·The British Journal of Dermatology·M J HaytonN J Lowe
Jan 8, 2004·The Journal of Investigative Dermatology·Maurice A M van SteenselFrances J D Smith
Jul 29, 2004·Journal of the American Academy of Dermatology·John HornbergerUNKNOWN Multi-Specialty Working Group on the Recognition, Diagnosis, and Treatment of Primary Focal Hyperhidrosis

❮ Previous
Next ❯

Citations

Aug 28, 2007·Journal of Dermatological Science·Haihui LiaoFrances J D Smith
Feb 22, 2011·Journal of Cosmetic Dermatology·Amir FeilyHossein Kalantar
Mar 30, 2010·The British Journal of Dermatology·M ZamiriC S Munro
May 8, 2010·Dermatologic Clinics·Anders Vahlquist, Kaisa Tasanen
Mar 28, 2017·The British Journal of Dermatology·L RittiéF J D Smith
Apr 8, 2017·Aesthetic Surgery Journal·Joel SchlessingerJoely Kaufman
Oct 28, 2017·Journal of the American Podiatric Medical Association·Rebecca M PorterFrances J D Smith
Mar 19, 2019·The British Journal of Dermatology·R L WeinbergM J Caterina
Jul 12, 2020·American Journal of Clinical Dermatology·Tina S Alster, Iris S Harrison
Dec 27, 2019·The British Journal of Dermatology·B R Thomas, A Sahota
Sep 2, 2014·Dermatologic Therapy·Anna JirákováJana Hercogová
Aug 30, 2018·The British Journal of Dermatology·M A Krupiczojc, E A O'Toole
Oct 8, 2015·Dermatologic Therapy·Jéssica González-RamosPedro Herranz-Pinto
Feb 11, 2021·Toxins·Emanuela MartinaAnnamaria Offidani
Jun 12, 2021·The Journal of Investigative Dermatology·Tiffany T WuJoyce M C Teng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.