Treatment of pain with pancreatic extracts in chronic pancreatitis: results of a prospective placebo-controlled multicenter trial

J MössnerG Adler


According to the theory of negative feedback regulation of pancreatic enzyme secretion by proteases, treatment with pancreatic extracts has been proposed to lower pain in chronic pancreatitis by decreasing pancreatic duct pressure. We conducted a prospective placebo-controlled double blind multicenter study to investigate the effect of porcine pancreatic extracts on pain in chronic pancreatitis. 47 patients with pain (41 males, 6 females) due to chronic pancreatitis documented by sonography, endoscopic retrograde cholangiopancreatography, and CT were included. Exclusion criteria were steatorrhea above 30 g/day, gastric or pancreatic resections in the history, and serum bilirubin above 1.5 mg/dl. Patients received pancreatic extracts (acid-protected microtablets; Panzytrat -20,000; 5 x 2 capsules/day; proteases/capsule 1,000 Pharmacopoea europaea units) for 14 days followed by treatment with placebo for another 14 days or vice versa. Pain (graded from 0 to 3) and concomitant use of analgesics (N-butylscopolaminiumbromide and tramadol) were recorded by diary. Physical examination and blood chemistry were done at day -1, 15 and 29. Quantitative stool fat was determined at days -2/-1, 13/14 and 27/28. 43 patients completed the stud...Continue Reading


Jan 6, 2005·Der Internist·R MahlkeP G Lankisch
Mar 29, 2001·Current Gastroenterology Reports·P LayerP G Lankisch
Sep 12, 2000·Current Gastroenterology Reports·P P Toskes
Sep 28, 2007·Current Treatment Options in Gastroenterology·Ayman M Abdel Aziz, Glen A Lehman
Sep 2, 1999·The Surgical Clinics of North America·G Y WongM G Sarr
May 2, 2002·Journal of Gastroenterology and Hepatology·Rakesh Kumar TandonUNKNOWN Consensus Study Group
Jun 1, 1995·The New England Journal of Medicine·M L SteerS Freedman
Jan 23, 1999·Journal of Clinical Gastroenterology·P Layer, J Keller
Oct 6, 1999·Journal of Clinical Gastroenterology·M V ApteJ S Wilson
Apr 28, 2006·Journal of Gastroenterology and Hepatology·Andy NydeggerMark R Oliver
Aug 9, 2005·Postgraduate Medical Journal·V Gupta, P P Toskes
Jun 1, 1996·Postgraduate Medical Journal·S Sidhu, R K Tandon
Dec 5, 2003·Postgraduate Medical Journal·K K BarmanV Mohan
May 29, 2008·World Journal of Gastroenterology : WJG·Cathia Gachago, Peter V Draganov
Nov 22, 2013·World Journal of Gastroenterology : WJG·Søren S OlesenAsbjørn M Drewes
Mar 13, 2014·Wiener medizinische Wochenschrift·Hana NechutovaMiroslav Soucek
Feb 12, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·E de-MadariaJ Martínez
May 3, 2012·Gastroenterology Research and Practice·Adam J Goodman, Frank G Gress
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Savio G Barreto, Gino T P Saccone
May 4, 2013·Gastroenterología y hepatología·Enrique de-MadariaUNKNOWN Club Español Pancreático
Feb 22, 2012·Gastroenterology Clinics of North America·James Buxbaum
Feb 22, 2012·Gastroenterology Clinics of North America·Guru TrikudanathanSanthi Swaroop Vege
May 20, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Nathaniel S Winstead, C Mel Wilcox
May 30, 2007·Gastroenterology Clinics of North America·Kenneth E FasanellaDavid C Whitcomb
Mar 17, 2009·Alimentary Pharmacology & Therapeutics·J G Lieb, C E Forsmark
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·F BurtonUNKNOWN North American Pancreatic Study Group
Mar 15, 2006·Current Problems in Surgery·Syed A AhmedJeffry B Matthews
Aug 28, 1998·Gastroenterology·A L WarshawC Fernández-Del Castillo
Apr 30, 2002·Best Practice & Research. Clinical Gastroenterology·Beat GloorMarkus W Büchler
Mar 9, 2007·Orvosi hetilap·Beatrix Sármán, Zsolt Tulassay
Feb 15, 2015·Disease-a-month : DM·Thiruvengadam MunirajPriya A Jamidar
Jan 15, 2014·Scottish Medical Journal·P Paisley, J Kinsella
Sep 8, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Paul M HobbsDavid Y Graham
Feb 5, 2009·The American Journal of Gastroenterology·Luisa GuarnerJ-R Malagelada
Mar 2, 2006·Digestive Diseases·Roland H Pfutzer, Alexander Schneider
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Nusrat ShafiqSamir Malhotra
Oct 1, 1998·Journal of Clinical Gastroenterology·C S Pitchumoni
Sep 28, 2002·European Journal of Gastroenterology & Hepatology·Asif Khalid, David C Whitcomb
Oct 20, 2010·The Medical Journal of Australia·James ToouliUNKNOWN Australasian Pancreatic Club

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