Treatment of pancreatic exocrine deficiency

World Journal of Surgery
Martin Sarner

Abstract

In treating pancreatic exocrine insufficiency the diagnosis of a cause, wherever possible, is a first step. If there is an obstructing lesion, then its relief may be curative. Adequate management depends on dietary manipulation and enzyme replacement. A reduction in fat intake, with accentuation of protein and carbohydrate consumption, is recommended. For enzyme replacement, enteric-coated microspheres are required, taken with adequate acid-suppression with a proton-pump inhibitor. The enzyme supplements, using standard preparations of pancreatin, usually of porcine source, may be as much as 4 to 8 tablets per meal and should be taken with food. Endocrine insufficiency usually requires insulin.

Citations

Dec 7, 2013·World Journal of Gastroenterology : WJG·R PezzilliExocrine Pancreatic Insufficiency collaborative (EPIc) Group
Mar 20, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sofia RengmanStefan Pierzynowski
Sep 22, 2016·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·N TakemuraT Yamaguchi
Dec 1, 2017·The Cancer Journal·Michael W RabowSarah H Adkins
Jan 26, 2020·Cancers·R PezzilliMassimo Falconi
Mar 9, 2017·Polymers·Agnes SchulzeAndrea Prager
Aug 18, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Maria Q B Petzel, Leah Hoffman

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