PMID: 4906702Feb 7, 1970Paper

Treatment of Parkinsonism with Laevo-dopa

British Medical Journal
C Mawdsley

Abstract

Thirty-two patients with Parkinsonism were treated with L-dopa. Nine were markedly and 14 moderately improved. Twenty patients tolerated the drug well, derived definite improvement, and were treated for an average period of six months. Improvement was sustained during this period even though the average daily dosage of L-dopa was reduced. Dose-dependent side-effects occurred in 25 patients. It is suggested that dosage schedules should be flexible and tailored to the needs of each individual patient, and that treatment should be continued for six months before presuming it to be ineffective.It is concluded that L-dopa often ameliorates Parkinsonism for long periods, but its effect on the natural history of the disease is undertermined.

References

Apr 12, 1969·Lancet·D B CalneP Armitage
Jul 26, 1969·Lancet·R B Godwin-AustenH W Kok
Jan 1, 1968·European Neurology·U K Rinne, V Sonninen
Feb 16, 1967·The New England Journal of Medicine·G C CotziasL M Schiffer
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jan 1, 1963·Neurology·M GREER, C M WILLIAMS

❮ Previous
Next ❯

Citations

Aug 6, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·L M ShulmanW J Weiner
Feb 26, 1973·Zeitschrift für Neurologie·S LavyS Feldman
Jan 1, 1972·Zeitschrift für Neurologie·C Fehling
Jan 1, 1972·Zeitschrift für Neurologie·U K RinneT Sirtola
Mar 1, 1971·Irish Journal of Medical Science·S F Murphy
Jan 2, 1971·British Medical Journal·R C HughesJ N Walton
Aug 26, 1972·British Medical Journal·R B JenkinsH L Klawans
Oct 10, 1970·British Medical Journal·L Rivera-CalimlimJ R Bianchine
Jun 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·G G MarshR Ansel
Dec 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·R LeandersonA Persson
Jun 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·B CoxG M Yuill
Dec 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·G G Marsh, C H Markham
Feb 21, 1970·British Medical Journal
Jan 30, 1971·British Medical Journal
Aug 1, 1972·Australian and New Zealand Journal of Medicine·M Pollock, P B Jorgensen
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·R MarconiY Agid
Jul 1, 1971·Anaesthesia·I M MacIntyreJ P Beavis
Dec 11, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Stanley Fahn
Dec 1, 1972·Journal of the American Geriatrics Society·M Riklan
Jul 1, 1991·Journal of the American Geriatrics Society·J L Cummings
Apr 1, 1976·Journal of the American Geriatrics Society·J WenerS Wener
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J E Ahlskog, M D Muenter
Jun 4, 1971·Nature·C Mawdsley, C V Gamsu
Jan 1, 1972·Folia Psychiatrica Et Neurologica Japonica·K InanagaT Kotorii
May 1, 1971·Australian and New Zealand Journal of Medicine·A G Fisher
Apr 1, 1972·Canadian Psychiatric Association Journal·H MarsA Barbeau
Jun 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·R B Godwin-Austen
Oct 1, 1982·Scottish Medical Journal·B PentlandC Mawdsley
Jan 1, 1974·Acta Neurologica Scandinavica·M Iivanainen
Jul 1, 1978·Journal of the American Geriatrics Society·C Salzman, R I Shader
Mar 19, 1973·Archiv für Psychiatrie und Nervenkrankheiten·E SchneiderH Maxion
Jan 1, 1975·Acta Neurologica Scandinavica·D L McLellanR H Johnson
Jun 1, 1971·Arquivos de neuro-psiquiatria·F PompeuE Albuquerque
Apr 4, 1970·Nature·D B Calne, M Sandler
Jan 1, 1974·Archiv für Psychiatrie und Nervenkrankheiten·E Metzel, W U Weitbrecht
Mar 31, 1973·The Medical Journal of Australia·G A Broe, F I Caird
Oct 3, 1970·The Medical Journal of Australia·P J Landy
Apr 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H FellmanJ J Strandholm

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.