Treatment of patients with juvenile idiopathic arthritis (JIA) in a population-based cohort

Clinical Rheumatology
Jorge A Zamora-LegoffEric L Matteson

Abstract

A population-based cohort was utilized to evaluate medications and intra-articular injection utilization for patients with juvenile idiopathic arthritis (JIA) to inform clinical practice and further research. In a geographically defined population, all incident cases of JIA cases were identified between January 1, 1994 and December 31, 2013 based first on diagnosis code followed by medical chart confirmation. Medications and intra-articular glucocorticoid injections were abstracted. Predictors of the first disease-modifying antirheumatic drug (DMARD)/biologic and injections were reported as a hazard ratio (HR) with 95 % confidence intervals (CIs) adjusted for age and sex. Kaplan-Meier methods evaluated therapy at 6 months and 1 year. Injections were reported per 100 person-years (py) with 95 % CI using the Poisson methods. Seventy-one incident cases were identified. Forty-two (59 %) were female with mean age (standard deviation) at diagnosis of 8.2 (5.3) years. Twenty-six (37 %) utilized at least one DMARD or biologic, in which 77 % of these were prescribed in the first 6 months. Subtype of JIA was significantly associated with DMARDs/biologics (p < 0.001). Intra-articular injections were performed in 48 %. The rate of intra-ar...Continue Reading

References

May 12, 2011·Arthritis and Rheumatism·Ellen NordalUNKNOWN Nordic Study Group of Pediatric Rheumatology
Feb 14, 2012·Arthritis and Rheumatism·Timothy BeukelmanUNKNOWN Safety Assessment of Biological Therapeutics Collaboration
Aug 4, 2012·The Journal of Rheumatology·Timothy BeukelmanUNKNOWN CARRA Registry Investigators
May 21, 2014·Annals of the Rheumatic Diseases·Jaime GuzmanUNKNOWN ReACCh-Out investigators
Sep 1, 2015·Arthritis & Rheumatology·Megan L KrauseEric L Matteson

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Citations

Jan 24, 2019·International Journal of Molecular Sciences·Giovanna FerraraRolando Cimaz
Jun 1, 2019·Arthritis Care & Research·Beverly KhodraElizabeth D Ferucci
May 18, 2020·Clinical Rheumatology·Manasita TanyaThaschawee Arkachaisri

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