Treatment of Patients With Late-Stage Colorectal Cancer: ASCO Resource-Stratified Guideline.

JCO Global Oncology
E Gabriela ChioreanMary D Chamberlin

Abstract

To provide expert guidance to clinicians and policymakers in resource-constrained settings on the management of patients with late-stage colorectal cancer. ASCO convened a multidisciplinary, multinational Expert Panel that reviewed existing guidelines, conducted a modified ADAPTE process, and used a formal consensus process with additional experts for two rounds of formal ratings. Existing sets of guidelines from four guideline developers were identified and reviewed; adapted recommendations from five guidelines form the evidence base and provided evidence to inform the formal consensus process, which resulted in agreement of ≥ 75% on all recommendations. Common elements of symptom management include addressing clinically acute situations. Diagnosis should involve the primary tumor and, in some cases, endoscopy, and staging should involve digital rectal exam and/or imaging, depending on resources available. Most patients receive treatment with chemotherapy, where chemotherapy is available. If, after a period of chemotherapy, patients become candidates for surgical resection with curative intent of both primary tumor and liver or lung metastatic lesions on the basis of evaluation in multidisciplinary tumor boards, the guidelines...Continue Reading

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Citations

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Methods Mentioned

BETA
surgical resection
biopsies
biopsy

Clinical Trials Mentioned

NCT02928224

Software Mentioned

ESMO
BRIDGE
GLOBOCAN
Wiz

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