Treatment of pediatric localized scleroderma: results of a survey of North American pediatric rheumatologists

The Journal of Rheumatology
Suzanne LiKathleen M O'Neil

Abstract

We surveyed pediatric rheumatologists (PR) in North America to learn how they treat pediatric localized scleroderma (LS), a disease associated with significant morbidity for the growing child. A Web-based survey was sent to the 195 PR members of the pediatric rheumatology research alliance CARRA (Childhood Arthritis and Rheumatology Research Alliance). Members were asked which medications they use to treat LS and which factors modify their treatment strategies. Clinical vignettes were provided to learn the specific treatment regimens used. A total of 158 PR from over 70 clinical centers in the United States and Canada participated in the survey, representing 81% of the CARRA membership. These PR saw over 650 patients with LS in the prior year. Nearly all respondents treated LS with methotrexate (MTX) and corticosteroids; most of them intensify treatment for lesions located on the face or near a joint, and about half intensify treatment for recent disease onset (< 6 months). Most PR reserve topical medications for limited treatment situations. Clinical vignettes showed that PR use a broad range of treatment doses and durations for MTX and corticosteroids. Most PR in North America treat localized scleroderma with a combination of...Continue Reading

References

Jan 1, 1994·Pediatric Radiology·P LiuR Laxer
Apr 1, 1994·Seminars in Arthritis and Rheumatism·Y UzielR M Laxer
Jun 1, 1997·Journal of the American Academy of Dermatology·H StegeJ Krutmann
Feb 3, 1998·Journal of the American Academy of Dermatology·M KerscherP Altmeyer
Aug 15, 1998·Journal of the American Academy of Dermatology·M M SeygerE M de Jong
Jan 15, 2000·The Journal of Pediatrics·Y UzielR M Laxer
Dec 1, 1956·A.M.A. Archives of Dermatology·H B CHRISTIANSONP A O'LEARY
Jun 14, 2005·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Jon VeloskiDavid B Nash
Jul 20, 2005·Archives of Dermatology·Alexander KreuterPeter Altmeyer
Sep 6, 2005·Arthritis and Rheumatism·Francesco ZulianUNKNOWN Juvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES)
Sep 27, 2005·The British Journal of Dermatology·M DytocL Fiorillo
Feb 21, 2006·Journal of the American Academy of Dermatology·Alexander KreuterThilo Gambichler
Sep 13, 2006·Clinics in Dermatology·Lorinda ChungDavid Fiorentino
Oct 21, 2006·Current Opinion in Rheumatology·Ronald M Laxer, Francesco Zulian
May 4, 2007·The British Journal of Ophthalmology·Maria Elisabetta ZanninUNKNOWN Juvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES)
Jun 8, 2007·The British Journal of Dermatology·M T DytocP T Ting
Mar 11, 2008·Rheumatic Diseases Clinics of North America·Francesco Zulian

❮ Previous
Next ❯

Citations

Apr 14, 2011·Nature Reviews. Rheumatology·Aimee HershEd Yelin
Jul 7, 2011·Rheumatology·Ariane L HerrickEileen M Baildam
May 23, 2014·Rheumatology·Daniel P HawleyHelen E Foster
Jun 27, 2012·Journal of the American Medical Informatics Association : JAMIA·Marc D NatterKenneth D Mandl
Oct 23, 2015·Indian Journal of Pediatrics·Liza J McCann, Clare E Pain
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Ivan Foeldvari
May 9, 2012·Pediatric Clinics of North America·Kathryn S Torok
Mar 3, 2012·Journal of the American Academy of Dermatology·Weilan Johnson, Heidi Jacobe
Jun 8, 2011·Journal of the American Academy of Dermatology·Brittany A Zwischenberger, Heidi T Jacobe
Jul 17, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Xiao Song LiuHong Hua
Sep 8, 2011·The British Journal of Dermatology·L WeibelJ I Harper
Feb 10, 2011·Arthritis and Rheumatism·Ivan Foeldvari
Nov 4, 2015·Pediatrics in Review·Danielle MagriniLakshmi N Moorthy
Mar 17, 2015·Journal of the American Academy of Dermatology·Nicole StricklandHeidi Jacobe
Feb 13, 2015·Anais Brasileiros De Dermatologia·Mariana Figueiroa Careta, Ricardo Romiti
Feb 14, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Elena PopeRonald M Laxer
Mar 17, 2015·Journal of Cutaneous Medicine and Surgery·Jennifer LipsonSuneil Kapur
Sep 17, 2018·The Journal of Rheumatology·Suzanne C LiKathryn S Torok
Oct 14, 2018·The British Journal of Dermatology·K L KurzinskiK S Torok
Mar 4, 2019·Annals of the Rheumatic Diseases·Francesco ZulianIvan Foeldvari
Dec 2, 2019·World Journal of Pediatrics : WJP·Suzanne C Li, Rong-Jun Zheng
Jan 23, 2020·Pediatric Dermatology·Ngan DoHeather Brandling-Bennett
May 8, 2018·European Journal of Pediatrics·Tamás ConstantinKathryn S Torok
Nov 23, 2017·Pediatric Dermatology·Megha M TollefsonElena Pope
Jul 23, 2018·Pediatric Clinics of North America·Suzanne C Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Rheumatology
Ronald M Laxer, F Zulian
Arthritis and Rheumatism
F ZulianJuvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES)
Rheumatology
F ZulianJuvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES)
© 2022 Meta ULC. All rights reserved