Treatment of Pediatric Pulmonary Hypertension

Current Treatment Options in Cardiovascular Medicine
Manish Aggarwal, R Mark Grady

Abstract

Pulmonary hypertension (PH) is an increasingly recognized problem in children, particularly within tertiary pediatric hospitals. This increase is, in large part, due to ever improving survival among previously fatal conditions, such as extreme prematurity and complicated congenital heart disease. This increased recognition has paralleled burgeoning pharmacologic and interventional PH-specific treatment options. Unfortunately, most PH-specific therapies have not been tested in children with rigorous, randomized, controlled trials. As a result, most treatment of PH in children is based upon expert consensus and practitioners' experience. In this article, we highlight some of the current and recent advances in therapies available for children with PH. The role that a Potts shunt may have in ameliorating severe PH in children is highlighted.

References

Nov 1, 1991·Catheterization and Cardiovascular Diagnosis·M R NihillC E Mullins
Apr 24, 2003·Clinical Pharmacology and Therapeutics·Robyn J BarstPaul L M van Giersbergen
Oct 27, 2006·Heart·Astrid E LammersSheila G Haworth
Dec 22, 2006·International Journal of Cardiology·M G J DuffelsB J M Mulder
Sep 22, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael A MathierRajan Saggar
Dec 24, 2010·The European Respiratory Journal·A A HislopS G Haworth
May 31, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Brian S GoldsteinR Mark Grady
Dec 6, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kristina KempOlivier Sitbon
Jan 5, 2012·Chest·Laura C PriceMarc Humbert
Mar 10, 2012·Pediatric Cardiology·Shinichi TakatsukiDavid Dunbar Ivy
Aug 25, 2012·The American Journal of Cardiology·Usha KrishnanErika B Rosenzweig
Jul 26, 2013·The New England Journal of Medicine·Hossein-Ardeschir GhofraniUNKNOWN PATENT-1 Study Group
Aug 30, 2013·The New England Journal of Medicine·Tomás PulidoUNKNOWN SERAPHIN Investigators
Dec 21, 2013·Journal of the American College of Cardiology·D Dunbar IvyMaurice Beghetti
Jul 10, 2014·Pulmonary Circulation·Chelsey M McIntyreE Zachary Ramsey
Dec 6, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alban-Elouen BaruteauDamien Bonnet
Dec 17, 2014·The American Journal of Pathology·Benoît RanchouxFrédéric Perros
Jul 8, 2015·Pediatrics·Bryan G MaxwellLewis H Romer
Aug 27, 2015·The New England Journal of Medicine·Nazzareno GalièUNKNOWN AMBITION Investigators
Nov 1, 2015·The Annals of Thoracic Surgery·R Mark Grady, Pirooz Eghtesady
Nov 5, 2015·Circulation·Steven H AbmanUNKNOWN American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical C
Dec 25, 2015·The New England Journal of Medicine·Olivier SitbonP G Williams
Mar 10, 2017·Current Medical Research and Opinion·Hiroyoshi YamazakiMasahiro Murakami
May 17, 2017·Cardiology in the Young·Manish Aggarwal, Ronald Mark Grady
Jun 25, 2017·The Journal of Pediatrics·Usha KrishnanUNKNOWN Pediatric Pulmonary Hypertension Network (PPHNet)
Jul 14, 2017·Pediatric Cardiology·Roberto GallottiJuan Alejos

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