PMID: 8961871Dec 1, 1996Paper

Treatment of pemphigus vulgaris with brief, high-dose intravenous glucocorticoids

Archives of Dermatology
V P Werth

Abstract

To determine if intravenous high-dose "pulse" glucocorticoid therapy induced remission or reduced subsequent requirements for orally administered glucocorticoids in pemphigus vulgaris. Retrospective, case-controlled study. Academic referral center. Fifteen patients, all of whom had pemphigus vulgaris, were included in the analysis. The group comprised all patients with pemphigus vulgaris seen during 11.5 years who did not initially respond to low doses (< 40 mg/d) of prednisone and who were followed up for at least 500 days after beginning treatment. One group received very high-dose intravenous pulse(s) of methylprednisolone sodium succinate (Solu-Medrol) (n = 9). The other group did not receive intravenous pulse therapy (n = 6). Glucocorticoid dose and status of disease. Patients treated with pulse therapy and control patients treated with conventional oral prednisone had similar initial disease severity. Six of the 9 patients who received pulse therapy showed improvement of their pemphigus vulgaris, and 4 of the 9 had discontinued all glucocorticoids and were in remission at mean (+/- SEM) 269 +/- 27 days. They have continued in remission without receiving prednisone for a mean of 714 +/- 142 days. Therapeutic benefit was se...Continue Reading

Citations

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