Abstract
Alopecia areata is an autoimmune disease with no definitive treatment, and some cases persist despite standard therapies. Sulfasalazine has been reported to show success in the treatment of persistent cases of alopecia areata. Objective To assess the efficacy of sulfasalazine in cases of recalcitrant alopecia areata that do not respond to topical and intralesional corticosteroids, 5% minoxidil, or psoralen plus ultraviolet-A (PUVA) therapy. Thirty-nine patients with persistent alopecia areata received 3 g of oral sulfasalazine for 6 months, and terminal hair regrowth was quantified as no response, moderate response, or good response. A good response occurred in 10 of the 39 patients (25.6%), a moderate response in 12 (30.7%), and a poor or no response in 17 (43.5%). Sulfasalazine can be used as an alternative drug in patients with persistent alopecia areata.
References
Nov 1, 1989·Clinical and Experimental Dermatology·F B De Waard-van der SpekJ D Peereboom-Wynia
Nov 1, 1995·British Journal of Rheumatology·G Smedegård, J Björk
Mar 22, 2002·Journal of the American Academy of Dermatology·Charles N EllisJohn J Voorhees
Aug 28, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P Freyschmidt-PaulR Hoffmann
Sep 1, 2004·Journal of the American Academy of Dermatology·Elise A OlsenUNKNOWN National Alopecia Areata Foundation
Citations
Aug 13, 2011·Clinical, Cosmetic and Investigational Dermatology·Adel Alsantali
Aug 27, 2013·Indian Journal of Dermatology, Venereology and Leprology·Kolalapudi Anjaneyulu Seetharam
Feb 2, 2010·Journal of the American Academy of Dermatology·Abdullah AlkhalifahJerry Shapiro
Jun 22, 2011·Dermatologic Therapy·Nina Otberg
Apr 25, 2012·The British Journal of Dermatology·A G MessengerM Sladden
Feb 18, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·M OmidianB Cheraghian
Nov 20, 2012·Dermatologic Clinics·Abdullah Alkhalifah
Sep 18, 2016·Clinics in Dermatology·Oliverio Welsh
Apr 6, 2017·International Journal of Dermatology·Sama KassiraFrancis Dann
Jun 22, 2017·The Journal of Dermatology·Solam Lee, Won-Soo Lee
Aug 12, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Vivien Wai Yun Lai, Rodney Sinclair
May 7, 2010·The Journal of Dermatological Treatment·Gokhan OkanMurat Saruc
Oct 12, 2018·Journal of Cosmetic Dermatology·Abdel-Aziz Ibrahim El-Taweel, Essam Mohamed Akl
Oct 4, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Alfredo RossiMaria C Fortuna
Jan 3, 2021·Clinical and Experimental Medicine·A SterkensA Bervoets
Sep 3, 2020·JAAD Case Reports·Leila K AsadiMing H Jih
Jul 23, 2009·Current Opinion in Pediatrics