Abstract
The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study. Patients with progressive Kaposi's sarcoma were eligible, and were staged according to ACTG criteria. Treatment consisted of 20 mg/m2 doxorubicin, and a fixed dose of 15 mg bleomycin and 4 mg vindesine every 2 weeks. All patients continued antiretroviral medication with severe myelosuppression, patients received subcutaneous 5 micrograms/kg rh GM-CSF (Leucomax) from days 2-12. Response and toxicity were measured according to ACTG and WHO criteria. 27 patients were evaluable, 25 patients classified as having a poor prognosis. The response rate was 70% (3 CR, 16 PR), the duration of response was 18 weeks (range 8-25) and the median survival 30 weeks (range 4-63+). The cause of death was mostly opportunistic infection. 4 patients died of pulmonary Kaposi's sarcoma. The toxicity of this regimen was mainly myelosuppression and 13 patients were treated with rh GM-CSF. Complete recovery of the white blood cells occurred in seven of the 27 courses of rh GM-CSF (26%). No bacterial infections were recorded, but 5 patients (19%) developed an opp...Continue Reading
References
Oct 1, 1992·AIDS·M M GompelsA J Munro
Dec 1, 1992·AIDS·P S GillA Levine
Dec 1, 1992·AIDS·E CaumesM Gentilini
Sep 1, 1992·AIDS·W K RothM Stürzl
Jul 11, 1991·The Journal of Infectious Diseases·R T DaveyH C Lane
Mar 1, 1990·Cancer·P S GillA M Levine
Apr 1, 1991·The American Journal of Medicine·P S GillM Krailo
Jul 1, 1991·British Journal of Haematology·P A van der WouwS A Danner
Jan 20, 1990·Lancet·V BeralH W Jaffe
May 1, 1990·The Journal of the South Carolina Medical Association·P H O'Brien
Mar 1, 1987·The American Journal of Medicine·E P GelmannR Steis
Jul 1, 1989·The American Journal of Medicine·P S GillA M Levine
Mar 1, 1989·Annals of Internal Medicine·J E Groopman, D T Scadden
May 1, 1988·Annals of Neurology·S M de la MonteA K Bhan
Nov 26, 1988·Lancet·R de WitS A Danner
Sep 3, 1987·The New England Journal of Medicine·J E GroopmanD W Golde
Jul 1, 1986·The American Journal of Medicine·G U MeduriM B Zaman
Jan 1, 1987·Chest·S M GarayR Schinella
May 15, 1993·Lancet·C A PresantJ Presant
Feb 1, 1987·Cancer·J E Groopman
Citations
Oct 1, 1996·Hematology/oncology Clinics of North America·F C Lee, R T Mitsuyasu
Mar 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M J Zalla
Jan 1, 1997·Dermatologic Clinics·R R Walther
Jan 1, 1997·Scandinavian Journal of Infectious Diseases
Nov 20, 1998·Journal of Chemotherapy·A MastroianniF Chiodo