Treatment of post-herpes zoster pain with tramadol. Results of an open pilot study versus clomipramine with or without levomepromazine

Drugs
H Göbel, T Stadler

Abstract

To date, no universally applicable recommendations are available for the treatment of patients with postherpetic neuralgia. A mixture of clinical anecdotes, experimental findings and observations from clinical trials form the basis of the medical arsenal for this condition. Tricyclic antidepressants are commonly used, and clinical experience and several investigations have documented their effectiveness. Today, single entity antidepressants, which can be combined with neuroleptics to increase analgesia, are generally recommended for the treatment of postherpetic neuralgia. Some authors also recommend the additional administration of an opioid if analgesia is inadequate. Just over a decade ago, opioids were considered ineffective for the treatment of neuropathic pain; however, more recent investigations relating to the use of opioids, primarily in the treatment of nontumour-related chronic pain, have led to a revision of their use in neuropathic pain. Nevertheless, the use of opioid therapy for neurogenic pain remains controversial. Tramadol is a synthetic, centrally acting analgesic with both opioid and nonopioid analgesic activity. The nonopioid component is related to the inhibition of noradrenaline (norepinephrine) reuptake ...Continue Reading

Citations

Aug 24, 2006·Expert Opinion on Pharmacotherapy·Consalvo Mattia, Flaminia Coluzzi
Mar 21, 2007·American Journal of Physical Medicine & Rehabilitation·Harden R Norman
Sep 19, 2017·Expert Opinion on Drug Discovery·Lidia BravoEsther Berrocoso
Apr 20, 2000·The Annals of Pharmacotherapy·P W HugenY A Hekster
Mar 11, 2005·Expert Opinion on Emerging Drugs·Lukas Radbruch, Frank Elsner
Dec 21, 2006·Clinical Drug Investigation·Daniel Arbaiza, Oscar Vidal
Jul 5, 2019·Drugs & Aging·Barbara Kleinmann, Tilman Wolter
Oct 19, 2007·The Cochrane Database of Systematic Reviews·T Saarto, P J Wiffen
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