Treatment of Primary Autoimmune Cerebellar Ataxia with Mycophenolate.

The Cerebellum
Marios HadjivassiliouNigel Hoggard

Abstract

Immune-mediated ataxias account for a substantial number of sporadic otherwise idiopathic ataxias. Despite some well-characterised entities such as paraneoplastic cerebellar degeneration where diagnostic markers exist, the majority of immune ataxias remained undiagnosed and untreated. We present here our experience in the treatment of suspected primary autoimmune cerebellar ataxia (PACA) using mycophenolate. All patients reported attend the Sheffield Ataxia Centre on a regular basis and had undergone extensive investigations, including genetic testing using next-generation sequencing, with other causes of ataxia excluded. The diagnosis of PACA was strongly suspected based on investigations, pattern of disease progression, and cerebellar involvement. Patients were treated with mycophenolate and monitored using MR spectroscopy of the cerebellar vermis. Thirty patients with PACA are reported here. Of these, 22 received mycophenolate (group 1). The remaining 8 were not on treatment (group 2-control group). Out of the 22 treated patients, 4 underwent serial MR spectroscopy prior to starting treatment and thus were used as controls making the total number of patients in the control group 12. The mean change of the MRS within the verm...Continue Reading

References

Feb 10, 2007·Autoimmunity Reviews·Luca IaccarinoAndrea Doria
Jun 12, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Marios HadjivassiliouG Aelwyn B Davies-Jones
Mar 24, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Gülin OzChristopher M Gomez
Feb 26, 2013·Journal of Neuroradiology. Journal De Neuroradiologie·Marius HadjivassiliouNigel Hoggard
Sep 4, 2015·Cerebellum & Ataxias·Robert D SandlerMarios Hadjivassiliou
Sep 29, 2015·JAMA Neurology·Amy L JonesAndrew McKeon
Nov 13, 2015·Cerebellum & Ataxias·Hiroshi MitomaJérôme Honnorat
Dec 15, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·M HadjivassiliouN Hoggard
Jul 21, 2017·Neurology·Marios HadjivassiliouNigel Hoggard
Oct 12, 2018·Nutrients·Marios HadjivassiliouNigel Hoggard
Mar 25, 2019·Journal of Neuroimmunology·Xiaolu XuHongzhi Guan

❮ Previous
Next ❯

Citations

Feb 18, 2021·Cerebellum & Ataxias·Marios HadjivassiliouMohammed Akil
Jun 15, 2021·Cerebellum & Ataxias·Laurence NewrickMarios Hadjivassiliou
Dec 1, 2021·Current Opinion in Neurology·João Lemos, Mario Manto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.