Treatment of primary intraocular melanoma

Expert Review of Anticancer Therapy
Bertil Damato

Abstract

The treatment of intraocular melanoma has evolved recently. Enucleation has been superseded largely by brachytherapy, proton beam radiotherapy, stereotactic irradiation, trans-scleral local resection, transretinal resection and diode laser phototherapy. Many patients develop metastatic disease, which usually involves the liver and occurs hematogenously. Disseminated disease rarely responds to therapy, and is usually fatal within 1 year of the onset of symptoms. Uveal melanomas develop characteristic chromosomal abnormalities, such as loss of chromosome 3. This is associated with a reduction in the 5-year survival from approximately 95% to less than 50%.

References

Mar 3, 1995·International Journal of Cancer. Journal International Du Cancer·V BatailleJ A Bishop
Oct 1, 1993·The British Journal of Ophthalmology·B E DamatoW S Foulds
Feb 1, 1996·The British Journal of Ophthalmology·B E DamatoW S Foulds
Feb 1, 1996·The British Journal of Ophthalmology·B E DamatoW S Foulds
Jan 1, 1997·Frontiers of Radiation Therapy and Oncology·B Damato
Oct 6, 1997·International Journal of Radiation Oncology, Biology, Physics·M A AstrahanZ Petrovich
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·I K DaftariE A Blakely
May 9, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·L MissottenE Van Limbergen
May 29, 1998·The British Journal of Ophthalmology·B DamatoD Wong
Jul 29, 1999·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J J AugsburgerL W Brady
Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis
Feb 24, 2001·The British Journal of Ophthalmology·B DamatoJ M Mackenzie
Jun 30, 2001·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·B Damato
Jul 27, 2001·Archives of Ophthalmology·M Diener-WestUNKNOWN Collaborative Ocular Melanoma Study Group
Sep 1, 2001·American Journal of Ophthalmology·P T Finger
Feb 28, 2002·The British Journal of Ophthalmology·S Eskelin, T Kivelä
Jun 5, 2002·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N BornfeldG A Horstmann
Dec 3, 2002·International Journal of Radiation Oncology, Biology, Physics·Paul T FingerAndrzej Szechter
Dec 10, 2002·Archives of Ophthalmology·Evangelos GragoudasKathleen M Egan
Jan 9, 2003·Cancer·Sebastian EskelinTero Kivelä
Feb 13, 2003·Ophthalmology·Patrick De Potter, Jacques Jamart
Feb 18, 2003·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A J MuellerA Kampik
Apr 25, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jens ReimerGabriele Helga Franke
Jun 19, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karin DieckmannRichard Pötter
Jul 2, 2003·American Journal of Ophthalmology·Devron H CharTheodore L Phillips
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Emma KujalaTero Kivelä
Nov 12, 2003·The British Journal of Ophthalmology·Y M BartlemaJ E E Keunen
Jan 9, 2004·Ophthalmology·Peter W HaddenBertil E Damato

❮ Previous
Next ❯

Citations

Jun 20, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E M DamatoS E Coupland
Oct 15, 2013·Current Oncology Reports·Sapna P Patel
Dec 24, 2009·Biological Procedures Online·Nakul MandalHenrik Vorum
Feb 17, 2009·Cancer Investigation·Andrew S KennedyWilliam A Dezarn
Jun 13, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Christine LawE Rand Simpson
Jan 25, 2012·Cancer Treatment Reviews·Francesco SpagnoloPaola Queirolo
Sep 29, 2011·International Journal of Radiation Oncology, Biology, Physics·Roman DunavoelgyiRichard Poetter
Apr 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karijn M S VerschuerenCorrie A M Marijnen
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Laura MarucciJohn E Munzenrider
Aug 28, 2007·Ophthalmology·Bertil DamatoPeter Howard
Dec 1, 2010·Acta Ophthalmologica·Fidan JmorSarah E Coupland
Mar 13, 2014·Clinical & Experimental Ophthalmology·Fan ZhangXu-Fang Sun
Mar 23, 2012·Brachytherapy·Daniel Grossi MarconiMaria Marta Motono Chojniak
Aug 26, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karin MullerGré P M Luyten
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael BradaDirk De Ruysscher
Apr 12, 2014·Melanoma Research·Marius L HaiducuSunil Kalia
Oct 1, 2008·British Journal of Cancer·C H Ottensmeier, M Gore
Jul 28, 2010·British Journal of Cancer·B Damato
Dec 21, 2019·Current Oncology Reports·Alessandro A E TestoriAlexander C J van Akkooi
Apr 30, 2013·Melanoma Research·Francesco SpagnoloPaola Queirolo
Feb 24, 2009·Journal of Neuro-oncology·Faruk ZorluHayyam Kiratli
Feb 1, 2019·Cancers·Eric FountainSapna P Patel
Jun 1, 2018·Oncology and Therapy·Manni SinghJensen Yeung
Sep 12, 2020·Cancers·Cristina Rodriguez-VidalManuel Bande
Oct 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bertil DamatoSarah E Coupland
Nov 26, 2019·International Journal of Pharmaceutics·Lingxiao XieJie Shen
Oct 1, 2020·International Journal of Molecular Sciences·Kashmiri LandeRoy Karnati
May 21, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Fatih Biltekin, Gozde Yazici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical & Experimental Ophthalmology
Bertil Damato
International Journal of Radiation Oncology, Biology, Physics
Rémi DendaleLaurence Desjardins
The British Journal of Ophthalmology
Bertil DamatoD Wong
The British Journal of Ophthalmology
D H CharJ B Crawford
© 2022 Meta ULC. All rights reserved