Treatment of progressive multiple sclerosis: Challenges and promising perspectives

Revue neurologique
E Maillart

Abstract

Management of progressive multiple sclerosis (MS) is one of the main challenges of the new century. Based on our knowledge of pathophysiology, three therapeutic strategies are proposed: anti-inflammatory (ocrelizumab, siponimod…); remyelinating (opicinumab); and neuroprotective (high-dose biotin, ibudilast, simvastatin…). Nevertheless, despite recent promising positive clinical trials, new methodological approaches for therapeutic protocols with adaptable outcomes to assess progression are still needed.

References

May 4, 2001·Brain : a Journal of Neurology·J HobartA Thompson
Jun 13, 2001·Neurology·UNKNOWN Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-Beta-1a in MS (SPECTRIMS) Study Group
Sep 11, 2002·Neurology·J A CohenUNKNOWN IMPACT Investigators
Dec 31, 2002·Lancet·Hans-Peter HartungUNKNOWN Mitoxantrone in Multiple Sclerosis Study Group (MIMS)
Dec 3, 2005·Multiple Sclerosis : Clinical and Laboratory Research·M G GrassoS Paolucci
Mar 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C CollinUNKNOWN Sativex Spasticity in MS Study Group
Jul 26, 2008·Multiple Sclerosis : Clinical and Laboratory Research·B BrochetV Dousset
Mar 3, 2009·Lancet·Andrew D GoodmanUNKNOWN Fampridine MS-F203 Investigators
Aug 12, 2009·Multiple Sclerosis : Clinical and Laboratory Research·R A RudickA W Sandrock
Apr 3, 2010·Clinical Rehabilitation·V L Stevenson
Aug 28, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Jeremy ChatawayTim Friede
Sep 11, 2010·Multiple Sclerosis : Clinical and Laboratory Research·R B C KaviaC J Fowler
Oct 27, 2010·Annals of Neurology·Andrew D GoodmanUNKNOWN MSF204 Investigators
Jul 5, 2012·Multiple Sclerosis : Clinical and Laboratory Research·T KjølhedeU Dalgas
Aug 25, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Robert J FoxKim Zuidwijk
Feb 1, 2013·Brain : a Journal of Neurology·Tarunya ArunJacqueline Palace
Mar 4, 2014·Therapeutic Advances in Neurological Disorders·Henrik Boye JensenEgon Stenager
May 30, 2014·Neurology·Fred D LublinChris H Polman
Mar 17, 2015·Lancet Neurology·Anthony FeinsteinAlbert C Lo
Mar 17, 2015·Lancet Neurology·Daniel OntanedaJeremy Chataway
Apr 2, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Jonatan Salzer
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Raymond HuppertsJacob Elkins
Jan 6, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Afsaneh ShiraniOlaf Stüve

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