PMID: 9540763Apr 16, 1998Paper

Treatment of prolymphocytic leukemia with cladribine

Annals of Hematology
I Lorand-MetzeF J Aranha

Abstract

Prolymphocytic leukemia (PLL) is a rare lymphoproliferative disorder that takes a rapidly progressive course and where therapeutic interventions are often unsuccessful. In this context, the new purine analogs may be a promising option. We report two cases of PLL treated with cladribine. The first patient had been resistant to polychemotherapy (COP) but responded well to two courses of 2-CdA. He achieved a partial remission, which he maintained for 15 months. The second patient had very advanced disease but obtained a partial response after three courses of 2-CdA, given as a first-line therapy in an ambulatory setting. These results, as well others reported in the literature, permit us to consider 2-CdA as a highly promising therapeutic option for PLL.

Citations

May 5, 2005·Current Treatment Options in Oncology·Ahmed AbsiMatt Kalaycio
May 1, 2001·British Journal of Haematology·S SallahN P Nguyen
Jul 31, 2010·Journal of Oncology·Amar B SinghPunita Dhawan
Apr 7, 2004·Cancer Genetics and Cytogenetics·Philip KuriakoseDaniel L Van Dyke
Mar 22, 2006·Seminars in Hematology·Claire E Dearden
Dec 8, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Matt E KalaycioMukta Arora

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